Asian Pacific Journal of Cancer Biology http://waocp.com/journal/index.php/apjcb <p><em>The Asian Pacific Journal of Cancer Biology (APJCB) is an open access electronic journal,&nbsp;which covers all aspects related to cancer biology. </em><em>&nbsp;</em><em>The journal was launched in 2016 as the official publication of Asian Pacific Organization for Cancer Preventiont (APOCP) by its west Asia Chapter (West asia Organization for Cancer prevention -WAOCP) .&nbsp; All manuscripts published in the Asia Pacific Journal of Cancer Biology, are under the terms of the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited.</em></p> en-US <p><em><img src="/journal/public/site/images/admin/Creative-Common.jpg" width="146" height="51">&nbsp;</em><em>West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).&nbsp;</em></p> apjcb@waocp.com (Hoda Golmahi) apjcb.waocp@gmail.com (Hoda Golmahi) Sun, 10 May 2020 08:20:50 +0100 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Expression of Villin associated with Epithelial to Mesenchymal Transition in patients with gastric cancer relating to their clinical and morphological specifications http://waocp.com/journal/index.php/apjcb/article/view/347 <p><strong>Aim and Background:</strong> Gastric cancer is the fourth most common cancer in the world and the second leading cause of cancer-related deaths. The metastatic invasive cells of tumor tissue are the main cause of mortality. Numerous biological phenomena are involved in organizing the metastatic process. The Epithelial to Mesenchymal Transition is one of the major mechanisms modulating malignant phenotypes by gastric epithelial cells. Specific cell signals are responsible for epithelial or mesenchymal maintenance of the cells in the tissue. These signals are evaluated by measuring the expression of epithelial and mesenchymal biomarkers in that tissue. Villin is an actin-binding protein mainly expressed in the brush border of epithelium which preserves the shape of the cell and its adhesion to the tissue. The aim of the present research is to study the expression of Villin in the cells as a feasible epithelial biomarker in order to evaluate the cross-sectional situation of the cells. <br><strong>Materials and Methods:</strong> 38 patients with gastric cancer that were admitted to the Cancer Institute of Imam Khomeini in a period of 6 months were chosen randomly. two samples were collected from each individual; one from the tumoral tissue and one from normal margin of the tumorous tissue. These samples were evaluated after obtaining informed consent from the patients. RNA was extracted from the samples and used as template for cDNA synthesis. The Villin expression was then measured through Real-Time PCR and statistical data according to tissue type and different grades were collected. <br><strong>Results:</strong> The expression of Villin in tumor tissue of the patients with gastric cancer was significantly lower than the normal tissue. <br><strong>Conclusion:</strong> As it appears decreased expression of Villin can act as an effective factor toward loss of epithelial nature of the cell and occurring Epithelial to Mesenchymal Transition followed by metastasis.<strong><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;"> </strong></p> Seyed Mohammad Azizi (Author) ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 http://waocp.com/journal/index.php/apjcb/article/view/347 Tue, 25 Feb 2020 07:56:17 +0000 Analysis of Chromosomal Aberrations and Micronuclei in Type 2 Diabetes Mellitus Patients http://waocp.com/journal/index.php/apjcb/article/view/350 <p><strong>Introduction:</strong> Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance and disrupted insulin secretion. It is often linked to injuries, malfunction and failure of several organs in the long term. The elevated chromosomal disruptions and genetic complications in diabetic patients are due to the increased production of reactive oxygen species.<br><strong>Materials and Methods:</strong> The current study used chromosomal aberration assay and micronucleus assay to analyze the extent of abnormalities in the subjects.<br><strong>Results:</strong> The results showed increase in frequency of chromosomal aberrations in diabetic patients when compared to the control group (2.76±1.65 and 0.47±0.75 respectively). They also showed higher levels of micronuclei formation than the control participants (13.28±8.63 and 4.12±8.89 respectively).The correlation analysis indicated positive relationship between total aberrations and duration of diabetes.<br><strong>Conclusion:</strong> These results indicate that diabetes is associated with genomic instability and studies at a genetic level can be employed for early detection.</p> Manikantan Pappuswamy, Nanditha Rajesh, Aaggi Maria Philip (Author) ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 http://waocp.com/journal/index.php/apjcb/article/view/350 Tue, 25 Feb 2020 08:03:04 +0000 Prevalence of Traditional and Complementary Alternative Medicine’s Use among Cancer Patients in South Peninsular Malaysia http://waocp.com/journal/index.php/apjcb/article/view/352 <p><strong>Objective:</strong> This study sought to describe the use of traditional and complementary alternative medicine’s (CAM) in a cohort of cancer patients in Johor, a state in Southern Peninsular Malaysia.<br><strong>Methodology:</strong> This is a four-month cross sectional study, targeted, on cancer outpatient clinics in three hospitals. Ethical approval and signed written informed consents were obtained from the patients, prior to the study. A standardised, interviewer-administered questionnaire was used to obtain the socio-demographic characteristics, clinical characteristics and questions on CAM’s use. <br><strong>Results:</strong> The response rate was 95.4%. The majority of the participants was females (79.9%) and was from the Malay ethnic group (79.2%) with most having only a secondary education (41.8%). The mean age was 57.7 ± 12.47 years with the majority having breast cancer (51.1%). There were no significant association between the socio demographic variables with CAM’s use with the exception of hospital, participants’ religion and ethnicity (p-value &lt; 0.05). Many patients preferred biologically-based therapies (87.8%) such as herbs and dietary supplements with a large proportion having reported to have utilised CAM after having completed the conventional treatment (40.0%). The majority (60.1%) of the patients were satisfied with CAM treatment while only 17.40% showed dissatisfaction. Most cancer patients chose CAM due to their perceived fewer side effects (31.1%), to increase quality of life (26.7%) and as a curative intent (20.7%).<br><strong>Conclusion:</strong> There is a high prevalence of CAM’s use among cancer patients in Southern State in Malaysia.</p> Nurul Huda Razali, Aisyah Ali, Siew Hua Gan, Chun Sen Lim (Author) ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 http://waocp.com/journal/index.php/apjcb/article/view/352 Tue, 25 Feb 2020 00:00:00 +0000 CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions http://waocp.com/journal/index.php/apjcb/article/view/344 <p>Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity. CDKs play important roles in the control of cell cycle progression, cell division, neuronal function, epigenetic regulation, metabolism, stem cell renewal and transcription. However, they can accomplish some of these tasks independently, without binding with cyclin protein or kinase activity. Thus, so far, twenty different CDKs and cyclins have been reported in mammalian cells. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). In this review, we summarizes that how CDKs are traditionally involve their latest revelations, their functional diversity beyond cell cycle regulation and their impact on development of disease in mammals.</p> <p>&nbsp;</p> Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq (Author) ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 http://waocp.com/journal/index.php/apjcb/article/view/344 Tue, 25 Feb 2020 07:48:50 +0000