The Role of Inflammatory and Nutritional Indices as a Predictive Markers in Multiple Myeloma Patients in the Egyptian Population

Authors

  • Hend A. Nooh Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
  • Samar S. El-Shazly Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
  • Safa Mohamed Nabawy Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
  • Ghada Nabil Elnaggar Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
  • Omnia M. Abo-Elazm Department of Biostatistics and Cancer Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt.
  • Ghada Nabil Shahin Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.

DOI:

https://doi.org/10.31557/APJCB.2026.11.3.747

Keywords:

Multiple Myeloma; Prognosis; Inflammatory indices; CBC

Abstract

Purpose: Multiple myeloma (MM) is a malignant proliferation of plasma cells which lead to a profound health affection.

Materials and Methods: 130 NDMM patients were included in this retrospective analysis. Patients’ clinico-pathological parameters, seven nutritional and inflammatory parameters were particularly noteworthy for investigation and correlation with disease stage, patient survival, and outcome.

Results: 53 patients (40.8%) were female, 77 patients (59.2%) were male, and the median patient age was 56.5 (47.8-64.0) years. High TLC count, pronounced anemia, and rouleaux development were all statistically significantly associated with R/ISS stage III (P=0.003), P=0.001), and P=0.010), respectively. Serum creatinine levels, low eGFR, elevated LDH, hypoalbuminemia, elevated phosphate, elevated B2 microglobulin were all significantly correlated with R/ISS stage III (P=0.001), (P=0.001), (P=0.001), (P=0.001), (P=0.001), and (P=0.002), (P=0.001), (P=0.001), respectively. The analysis of inflammatory and nutritional indices revealed that R/ISS stage I is linked to low NLR, high PNI index, and high AAPR (P=0.013), (P=0.021), and (P=0.027), respectively, while R/ISS stage III is linked to an elevated iP/L ratio (P=0.014). Low PLR is also linked to R/ISS stage III, however the difference was not statistically significant. Following a 21-month follow-up, the cumulative OS is 37.7%, and the median OS is 29.2 months with 95% CI (22.65-35.75). Patients with low PNI and those with high NLR have worse OS (P=0.014 and P=0.029), respectively. Cox regression Multivariate analysis showed that elevated NLR is considered an independent predictor of worse overall survival.

Conclusion: The study findings highlight the prognostic relevance of systemic inflammation and nutritional status in survival outcomes of NDMM patients.

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Published

2026-07-13

How to Cite

1.
Nooh HA, El-Shazly SS, Nabawy SM, Elnaggar GN, Abo-Elazm OM, Shahin GN. The Role of Inflammatory and Nutritional Indices as a Predictive Markers in Multiple Myeloma Patients in the Egyptian Population. Asian Pac J Cancer Biol [Internet]. 2026 Jul. 13 [cited 2026 Jul. 14];11(3):747-55. Available from: https://waocp.com/journal/index.php/apjcb/article/view/2506

Issue

Vol. 11 No. 3 (2026)

Section

Research Articles/ Original Work

License

Copyright (c) 2026 Asian Pacific Journal of Cancer Biology

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