<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving DTD v1.0 20120330//EN" "JATS-journalarchiving.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ali="http://www.niso.org/schemas/ali/1.0">
  <front>
    <article-meta>
      <title-group>
        <article-title>Reducing Unnecessary Emergency Department Visits among Cancer Patients</article-title>
      </title-group>
      <abstract>
        <p id="_paragraph-1">Recent studies showed that cancer patients’ visits to emergency departments are rising globally. This can be explained by the growing incidence of cancer and improved survival rates. Cancer patients’ visits to the ED can have detrimental effects that impact both the patients and the overall capability of the healthcare system. Cancer patients constantly need complex care, leading to longer ED stays and higher rates of admission in the hospital, which can strain ED resources and personnel. A significant number of ED visits by cancer patients are considered potentially avoidable. Establishing dedicated oncology outpatient clinics and applying early symptom detection and management pathways can reduce ED visits. Elaborating standardized pathways for controlling frequent symptoms (fever, pain, vomiting) and involving interdisciplinary teams can help manage symptoms in an outpatient clinic, reducing the need for ED visits. This brief communication emphasizes the importance of understanding this phenomenon to improve patient care and resource allocation in healthcare systems.</p>
      </abstract>
    </article-meta>
  </front>
  <body id="body">
    <sec id="heading-e3294513f91641806445b6b83cb478a8">
      <title>Introduction</title>
      <p id="paragraph-1">Recent publications showed that visits to emergency departments (EDs) by cancer patients are rising globally. This can be explained by both the growing incidence of cancer and the long-term response to the treatments used. The proportion and absolute number of ED visits by cancer patients have continuously increased over recent years. For example, in the United States, between 2006 and 2012, cancer-related ED visits accounted for 4.2% of all ED visits, with lung cancers, breast, and prostate being the most frequent diagnoses [1]. In Korea, the incidence rate of ED visits by cancer patients rose from 521.8 per 100,000 population in 2015 to 642.2 in 2019, reflecting a clear ascending trend [2]. The number of potentially avoidable ED visits among cancer patients in the US almost doubled from 1.8 million to 3.2 million between 2012 and 2019 [3]. The visits of the ED by cancer patients can have harmful consequences, impacting both the patients and the overall capability of the healthcare system.</p>
      <p id="paragraph-2" />
      <sec id="heading-febd256059a18a7ec6d28d4ae829a492">
        <title>
          <italic id="italic-1">Negative Effects on Cancer Patients</italic>
        </title>
        <p id="paragraph-4">Repeated ED visits are often interrelated with unmanaged pain, emotional distress, and complications from cancer or its treatment, all of which can impact quality of life for patients [4-6]. Cancer patients encountering emotional discomfort, such as anxiety or depression, have inferior clinical outcomes, comprising shorter survival and lower treatment response rates. ED visits can increase this distress, further affecting quality of life [4].</p>
        <p id="paragraph-798ef5f81c8f96fe450ecacd656e01dd">Many cancer patients receive opioids for pain control during ED visits. An important proportion (34%) is at high risk for opioid misuse, particularly those with depression or lowest coping skills, increasing concerns about addiction and related damage [5, 7]. EDs may not always be supplied to deliver specific cancer care, leading to poor management of complications and symptoms [5, 6].</p>
        <p id="paragraph-3" />
      </sec>
      <sec id="heading-a1e75ea199d1c686f90ff1f714ae681b">
        <title>
          <italic id="italic-67fdedd59c420974bb37ce783f82322c">Negative Effects on the ED System</italic>
        </title>
        <p id="paragraph-5">Cancer patients constantly need complex care, leading to longer ED stays and higher rates of admission in the hospital, which can strain ED resources and the personnel [5, 6]. A significant part of ED visits by cancer patients are considered potentially avoidable, most of the time related to pain or treatment side effects that could be managed in outpatient settings. This contributes to unnecessary ED overruns and increased healthcare costs [6]. The regular use of emergency departments by cancer patients, particularly for pain management and complications, increases overall healthcare costs and can shift resources away from other urgent cases [5, 6]. Enhancing the quality of cancer care can be achieved by minimizing avoidable emergency department visits for cancer patients.</p>
        <p id="paragraph-d559ffa5e898b7e538ca6dddeddb45f9" />
      </sec>
      <sec id="heading-72ff79f98b239b7dad3caa7587886eba">
        <title>
          <italic id="italic-88500f3318a5611b1886ee516fdd9975">Practical Strategies to Reduce Unnecessary ED Visits</italic>
        </title>
        <p id="paragraph-74b2edb82113bb633d4a924baf1aace8">Establishing dedicated oncology outpatient clinics and applying early symptom detection and management pathways can reduce ED visits. Multiple studies showed that such clinics and specific follow-up care reduce the proportion of patients visiting the ED, especially when care is harmonized and symptoms are handled proactively. [8-10] instructing patients to contact their oncology staff before visiting the ED, giving contact information, and periodic reminders during clinic visits have been proven to minimize preventable ED visits [10-12].</p>
        <p id="paragraph-1e44fd924eb9f7e5715d2f28ef5e65fb">Coordination, involving anticipated phone calls, helps distinguish and address symptoms early. Elaborating standardized pathways for controlling frequent symptoms (fever, pain, vomiting) and involving interdisciplinary teams (including palliative care) can help manage symptoms in outpatient clinic, reducing the need for ED visits [9, 10, 12].</p>
        <p id="paragraph-6">Predictive models and risk stratification, like machine learning tools, can help distinguish high-risk patients for potentially avoidable ED visits. These patients, frequently those with early-stage cancer, on systemic treatment, or with specific cancer types, may benefit most from proactive approach [13, 14].</p>
        <p id="paragraph-7">Some ED visits are required due to acute or significant complications. However, studies rate that about 30% of ED visits among cancer patients may be likely avoidable with better outpatient care and symptom control [12, 15]. Clinical specialist nurses (CNS) perform an important role in patient education, symptom management, and follow-up, all imperative for reducing unnecessary ED visits [16].</p>
        <p id="paragraph-8">CNS with the triage phone plays a crucial role in managing symptoms, reducing unnecessary ED visits, and improving quality of life [17]. This role is also vital in cancer patient education, proactive symptom management, and follow-up, all of which are essential for reducing unnecessary ED utilization [10, 11, 18-20].</p>
        <p id="paragraph-9">Increased contact with the CNS is linked to fewer ED visits and hospital admissions. Nurses dedicated to home care significantly decrease the probability of unnecessary interventions in the end of life [21, 22].</p>
        <p id="paragraph-10" />
      </sec>
      <sec id="heading-a773f46ed41998101777518289d992b7">
        <title>
          <italic id="italic-2">Impact and Outcomes</italic>
        </title>
        <p id="paragraph-12">Implementation of CNS and triage has led to better patient outcomes. This intervention also improves overall care quality and results in significant healthcare cost savings by preventing avoidable acute care use [10, 11, 16, 18-20, 22, 23].</p>
        <p id="paragraph-6989298e4db05f8d9cb7b27536920aba">Transition to patient-centered cancer care models, resulted in a 40% reduction in ED visits, hospital stays and other acute care services [24]. Establishing urgent care units specifically for cancer patients led to important decrease in ED visits. The median charge for an urgent care visit is $2,221 compared to $10,261 for an ED visit, showing significant per-visit cost savings [25]. Delivering supportive health education to cancer patients and health staff lowered urgent care and ED visits, resulting in cost savings varying from $800 to $17,000 per 100 survivors, basing on the type of service prevented [26].</p>
        <p id="paragraph-f85d187eb9ab19b0333d3858ca2ba378">Hospital-at-home care for cancer patients lowered unexpected admissions by 55% and ED visits by 45%, reducing overall healthcare costs by 47% [27]. Low-cost care coordination interventions, such as proactive symptom control and after-hours call systems, led to a 30% decline in ED visits without necessitating further staff or technology, further sustaining cost-effective care [11]. Avoiding aggressive treatments and unnecessary ED visits at the end of life can cleave the cost of care episodes, with patients having fewer ED visits incurring much lower average costs ($21,000 vs. $49,000 per episode) [28].</p>
        <p id="paragraph-f9b01962f66c52fa6fd6dd89f668adb1">In conclusion, the rising trend of emergency department visits among cancer patients emphasizes a pressing need for ameliorated outpatient care and proactive symptom management. To improve healthcare resources and patients’ quality of life, we need to handle the emotional and physical issues faced by these patients. early intervention and coordinated care can enhance manage symptoms, reduce healthcare costs, and improve patient outcomes.</p>
        <p id="paragraph-ddc1e7f47fe6401ea81e4acddf403c5c" />
        <p id="paragraph-50f970ae606fa636e83239fa58bbb454">
          <italic id="italic-5072ce2facd70d95516b0b47a28713d2">Declarations<italic id="italic-67e0a1a6b4acafaf45510df4b7602080"/></italic>
        </p>
        <p id="paragraph-8dcf527eba7680d12fba479a871d1f35">Ethics approval and consent to participate</p>
        <p id="paragraph-6347b80de7058277b1a4d3a1e9da026e" />
        <p id="paragraph-7e02cfe77c6abbf2c7703b816908603d">
          <italic id="italic-3">Not applicable</italic>
        </p>
        <p id="paragraph-9139a63494811111c491f8412ad58924">Consent for publication</p>
        <p id="paragraph-6016eab54f1275493866c9ed15fff2e5" />
        <p id="paragraph-11">
          <italic id="italic-4">Not applicable</italic>
        </p>
        <p id="paragraph-d373d7a1e0ecae9fb97854452abac72f">Availability of data and materials</p>
        <p id="paragraph-13" />
        <p id="paragraph-14">
          <italic id="italic-5">Not applicable Competing interests</italic>
        </p>
        <p id="paragraph-15">The authors declare that they have no competing interests.</p>
        <p id="paragraph-16" />
        <p id="paragraph-17">
          <italic id="italic-6">Funding<italic id="italic-7"/></italic>
        </p>
        <p id="paragraph-18">Not applicable</p>
        <p id="paragraph-19" />
      </sec>
    </sec>
    <sec id="heading-f3c1c1cf92169338e05fb429b25b44c3">
      <title>Acknowledgements</title>
      <p id="paragraph-20">Not applicable</p>
    </sec>
    <sec id="heading-08ac7dcebc4de62f83de09abef5feaf9">
      <title>References</title>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="journal-article-ref-ae16128b8b051cf837870a31afdb3589">
        <element-citation publication-type="journal">
          <day>12</day>
          <issue>10</issue>
          <month>10</month>
          <page-range>e172450</page-range>
          <volume>3</volume>
          <year>2017</year>
          <pub-id pub-id-type="doi">10.1001/jamaoncol.2017.2450</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Rivera DR</named-content>
            </collab>
            <name>
              <surname>Gallicchio</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Brown</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Liu</surname>
              <given-names>B</given-names>
            </name>
            <collab>
              <named-content content-type="name">Kyriacou DN</named-content>
            </collab>
            <name>
              <surname>Shelburne</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <source>JAMA Oncology</source>
          <article-title>Trends in Adult Cancer–Related Emergency Department Utilization: An Analysis of Data From the Nationwide Emergency Department Sample</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-2275c3f8c574a1d70b1f87e80f804f0b">
        <element-citation publication-type="journal">
          <day>09</day>
          <issue>1</issue>
          <month>11</month>
          <page-range>21981</page-range>
          <volume>11</volume>
          <year>2021</year>
          <pub-id pub-id-type="doi">10.1038/s41598-021-01571-1</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Lee SY</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Ro YS</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Shin SD</named-content>
            </collab>
            <name>
              <surname>Moon</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <source>Scientific Reports</source>
          <article-title>Epidemiologic trends in cancer-related emergency department utilization in Korea from 2015 to 2019</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-dbcd437c821e86ab58f7c0a2c10a5e79">
        <element-citation publication-type="journal">
          <day>19</day>
          <issue>1</issue>
          <month>01</month>
          <page-range>e2250423</page-range>
          <volume>6</volume>
          <year>2023</year>
          <pub-id pub-id-type="doi">10.1001/jamanetworkopen.2022.50423</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Alishahi Tabriz</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Turner</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Hong</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Gheytasvand</surname>
              <given-names>S</given-names>
            </name>
            <collab>
              <named-content content-type="name">Powers BD</named-content>
            </collab>
            <name>
              <surname>Elston Lafata</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <source>JAMA Network Open</source>
          <article-title>Trends and Characteristics of Potentially Preventable Emergency Department Visits Among Patients With Cancer in the US</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-b0122eb0cba9dfd141787f5af539689e">
        <element-citation publication-type="journal">
          <issue>6</issue>
          <month>06</month>
          <page-range>1680-1688</page-range>
          <volume>30</volume>
          <year>2024</year>
          <pub-id pub-id-type="doi">10.1038/s41591-024-02929-4</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Zeng</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Hu</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Li</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Zhou</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Wang</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Liu</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Qiu</surname>
              <given-names>Z</given-names>
            </name>
            <collab>
              <named-content content-type="name">et al</named-content>
            </collab>
          </person-group>
          <source>Nature Medicine</source>
          <article-title>Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-5c4263db3a2590938be1eb238562c004">
        <element-citation publication-type="journal">
          <day>01</day>
          <issue>16_suppl</issue>
          <month>06</month>
          <page-range>e24034-e24034</page-range>
          <volume>42</volume>
          <year>2024</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2024.42.16_suppl.e24034</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Nortey</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Lynch</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Lyon</surname>
              <given-names>L</given-names>
            </name>
            <collab>
              <named-content content-type="name">Ramalingam ND</named-content>
            </collab>
            <name>
              <surname>Liu</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Beyond the pain: Decoding opioid use in advanced cancer ED visits.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-1b505f14f8c4523cfa1b48e6f30f04f4">
        <element-citation publication-type="journal">
          <day>11</day>
          <issue>12</issue>
          <month>12</month>
          <page-range>1020-1033</page-range>
          <volume>28</volume>
          <year>2023</year>
          <pub-id pub-id-type="doi">10.1093/oncolo/oyad161</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Fleshner</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Lagree</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Shiner</surname>
              <given-names>A</given-names>
            </name>
            <collab>
              <named-content content-type="name">Alera MA</named-content>
            </collab>
            <name>
              <surname>Bielecki</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Grant</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Kiss</surname>
              <given-names>A</given-names>
            </name>
            <collab>
              <named-content content-type="name">et al</named-content>
            </collab>
          </person-group>
          <source>The Oncologist</source>
          <article-title>Drivers of Emergency Department Use Among Oncology Patients in the Era of Novel Cancer Therapeutics: A Systematic Review</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-32c43e91cbfe8f29d601fb20792debe9">
        <element-citation publication-type="journal">
          <issue>2</issue>
          <month>02</month>
          <page-range>151-158</page-range>
          <volume>23</volume>
          <year>2016</year>
          <pub-id pub-id-type="doi">10.1111/acem.12861</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Reyes-Gibby CC</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Anderson KO</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Todd KH</named-content>
            </collab>
          </person-group>
          <source>Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine</source>
          <article-title>Risk for Opioid Misuse Among Emergency Department Cancer Patients</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-56ac199f06e5696aa08d9f314a2181bd">
        <element-citation publication-type="journal">
          <issue>9</issue>
          <month>09</month>
          <page-range>4077-4094</page-range>
          <volume>28</volume>
          <year>2020</year>
          <pub-id pub-id-type="doi">10.1007/s00520-020-05490-1</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Kirkland SW</named-content>
            </collab>
            <name>
              <surname>Garrido-Clua</surname>
              <given-names>M</given-names>
            </name>
            <collab>
              <named-content content-type="name">Junqueira DR</named-content>
            </collab>
            <name>
              <surname>Campbell</surname>
              <given-names>S</given-names>
            </name>
            <collab>
              <named-content content-type="name">Rowe BH</named-content>
            </collab>
          </person-group>
          <source>Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer</source>
          <article-title>Preventing emergency department visits among patients with cancer: a scoping review</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-74b0879314ab57047643a3233f6ca789">
        <element-citation publication-type="journal">
          <day>20</day>
          <issue>30_suppl</issue>
          <month>10</month>
          <page-range>302-302</page-range>
          <volume>36</volume>
          <year>2018</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2018.36.30_suppl.302</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Roy</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Halbert</surname>
              <given-names>B</given-names>
            </name>
            <collab>
              <named-content content-type="name">Devlin SM</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Zerillo JA</named-content>
            </collab>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Symptom management pathways to reduce ED visits and hospitalizations for patients with cancer.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-0075f6263493de5ecf5db66a02a3fbc5">
        <element-citation publication-type="journal">
          <day>01</day>
          <issue>28_suppl</issue>
          <month>10</month>
          <page-range>337-337</page-range>
          <volume>40</volume>
          <year>2022</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2022.40.28_suppl.337</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Waugh</surname>
              <given-names>W</given-names>
            </name>
            <collab>
              <named-content content-type="name">Das DG</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Thomas NN</named-content>
            </collab>
            <name>
              <surname>Plotkin</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Salgia</surname>
              <given-names>R</given-names>
            </name>
            <collab>
              <named-content content-type="name">Spira AI</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Socinski MA</named-content>
            </collab>
            <collab>
              <named-content content-type="name">et al</named-content>
            </collab>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Reducing preventable ED visits in patients with advanced NSCLC: Collective insights from three cancer centers.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-c1857c6d28b3fa7f7fe51267aa02d78a">
        <element-citation publication-type="journal">
          <day>20</day>
          <issue>27_suppl</issue>
          <month>09</month>
          <page-range>100-100</page-range>
          <volume>37</volume>
          <year>2019</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2019.37.27_suppl.100</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Arrowsmith</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Suits</surname>
              <given-names>L</given-names>
            </name>
            <collab>
              <named-content content-type="name">Anz BM</named-content>
            </collab>
            <name>
              <surname>Geren</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Vasta</surname>
              <given-names>L</given-names>
            </name>
            <collab>
              <named-content content-type="name">Lyss AJ</named-content>
            </collab>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Reducing ED visits by “closing the loop” for symptomatic patients.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-906f5543b7acc62f18b9997a077b32d2">
        <element-citation publication-type="journal">
          <day>01</day>
          <issue>28_suppl</issue>
          <month>10</month>
          <page-range>241-241</page-range>
          <volume>39</volume>
          <year>2021</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2020.39.28_suppl.241</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Patwari</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Bhatlapenumarthi</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>Brann</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Waldrip</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Caruso</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>Hatch</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Curtis</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Chodkiewicz</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Analysis of reasons for Emergency Department (ED) visits and subsequent hospital admissions in patients with solid malignancies: A retrospective study from a cancer center in rural Maine.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-0b69541d6b263bfe6c0d973de670ff9e">
        <element-citation publication-type="journal">
          <issue>8</issue>
          <month>11</month>
          <page-range>e2400147</page-range>
          <year>2024</year>
          <pub-id pub-id-type="doi">10.1200/CCI-24-00147</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Fleshner</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Gandhi</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Lagree</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Boulard</surname>
              <given-names>L</given-names>
            </name>
            <collab>
              <named-content content-type="name">Grant RC</named-content>
            </collab>
            <name>
              <surname>Kiss</surname>
              <given-names>A</given-names>
            </name>
            <collab>
              <named-content content-type="name">Krzyzanowska MK</named-content>
            </collab>
            <collab>
              <named-content content-type="name">et al</named-content>
            </collab>
          </person-group>
          <source>JCO Clinical Cancer Informatics</source>
          <article-title>Identifying Oncology Patients at High Risk for Potentially Preventable Emergency Department Visits Using a Novel Definition</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-7d0c36796eec5a46ac5b43d5da11c4b2">
        <element-citation publication-type="journal">
          <issue>11_suppl</issue>
          <month>11</month>
          <page-range>463-463</page-range>
          <volume>19</volume>
          <year>2023</year>
          <pub-id pub-id-type="doi">10.1200/OP.2023.19.11_suppl.463</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Gandhi</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Fleshner</surname>
              <given-names>L</given-names>
            </name>
            <collab>
              <named-content content-type="name">Krzyzanowska MK</named-content>
            </collab>
            <name>
              <surname>Kiss</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Cheng</surname>
              <given-names>I</given-names>
            </name>
            <name>
              <surname>Tran</surname>
              <given-names>W</given-names>
            </name>
          </person-group>
          <source>JCO Oncology Practice</source>
          <article-title>Defining and evaluating potentially preventable ED visits in oncology patients including using early machine learning models.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-d96b4a89f2b98cc3080f62c717db1dea">
        <element-citation publication-type="journal">
          <day>01</day>
          <issue>28_suppl</issue>
          <month>10</month>
          <page-range>272-272</page-range>
          <volume>39</volume>
          <year>2021</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2020.39.28_suppl.272</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Manobianco</surname>
              <given-names>S</given-names>
            </name>
            <collab>
              <named-content content-type="name">Quinn ZL</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Csik VP</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Binder AF</named-content>
            </collab>
            <name>
              <surname>Handley</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Evaluating the utility of rule OP-35 to define preventability of ED visits for oncology patients at an academic cancer center.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-9b5fcecb421af691a650c2656a896295">
        <element-citation publication-type="journal">
          <issue>2</issue>
          <page-range>135-144</page-range>
          <volume>40</volume>
          <year>2017</year>
          <pub-id pub-id-type="doi">10.1097/NCC.0000000000000360</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Lash RS</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Bell JF</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Reed SC</named-content>
            </collab>
            <name>
              <surname>Poghosyan</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Rodgers</surname>
              <given-names>J</given-names>
            </name>
            <collab>
              <named-content content-type="name">Kim KK</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Bold RJ</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Joseph JG</named-content>
            </collab>
          </person-group>
          <source>Cancer Nursing</source>
          <article-title>A Systematic Review of Emergency Department Use Among Cancer Patients</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-8dd867efae5fc91243f99a7577d3b34c">
        <element-citation publication-type="journal">
          <issue>4</issue>
          <month>04</month>
          <page-range>e564-e574</page-range>
          <volume>17</volume>
          <year>2021</year>
          <pub-id pub-id-type="doi">10.1200/OP.20.00617</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Hong AS</named-content>
            </collab>
            <name>
              <surname>Chang</surname>
              <given-names>H</given-names>
            </name>
            <collab>
              <named-content content-type="name">Courtney DM</named-content>
            </collab>
            <name>
              <surname>Fullington</surname>
              <given-names>H</given-names>
            </name>
            <collab>
              <named-content content-type="name">Lee SJC</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Sweetenham JW</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Halm EA</named-content>
            </collab>
          </person-group>
          <source>JCO oncology practice</source>
          <article-title>Patterns and Results of Triage Advice Before Emergency Department Visits Made by Patients With Cancer</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-6c4227aade819287eb05140c07b159b3">
        <element-citation publication-type="journal">
          <issue>10_suppl</issue>
          <month>10</month>
          <page-range>342-342</page-range>
          <volume>20</volume>
          <year>2024</year>
          <pub-id pub-id-type="doi">10.1200/OP.2024.20.10_suppl.342</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Onime</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Okpara</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Affoon</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Korenke</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Betts</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Payan</surname>
              <given-names>I</given-names>
            </name>
            <name>
              <surname>Buschardt</surname>
              <given-names>V</given-names>
            </name>
            <collab>
              <named-content content-type="name">et al</named-content>
            </collab>
          </person-group>
          <source>JCO Oncology Practice</source>
          <article-title>Data-driven insights to increase utilization of an oncology acute care clinic.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-96828740fb64ce13312f4cbe0530156d">
        <element-citation publication-type="journal">
          <day>20</day>
          <issue>27_suppl</issue>
          <month>09</month>
          <page-range>82-82</page-range>
          <volume>37</volume>
          <year>2019</year>
          <pub-id pub-id-type="doi">10.1200/JCO.2019.37.27_suppl.82</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Rodgers GT</named-content>
            </collab>
            <name>
              <surname>Brusio</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Lindberg</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Savage</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Hooley</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Young</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Expansion of an oncology care coordination nurse model to reduce hospitalizations and emergency department utilization.</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-b4e075aed29527ffd51e9275dbdb755a">
        <element-citation publication-type="journal">
          <fpage>64</fpage>
          <issue>28_suppl</issue>
          <volume>40</volume>
          <year>2022</year>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Jensen TL</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Mikan SQ </named-content>
            </collab>
            <name>
              <surname>Books </surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Escudier </surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Pearson</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <source> J Clin Oncol</source>
          <article-title>Decreases in emergency department and hospitalization visits over 5 years of the Oncology Care Model</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-2b91ac6c3094dd1877647b57b12e6c66">
        <element-citation publication-type="journal">
          <day>23</day>
          <issue>2</issue>
          <month>02</month>
          <page-range>e054281</page-range>
          <volume>12</volume>
          <year>2022</year>
          <pub-id pub-id-type="doi">10.1136/bmjopen-2021-054281</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Leniz</surname>
              <given-names>J</given-names>
            </name>
            <collab>
              <named-content content-type="name">Henson LA</named-content>
            </collab>
            <name>
              <surname>Potter</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Gao</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Newsom-Davis</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Ul-Haq</surname>
              <given-names>Z</given-names>
            </name>
            <name>
              <surname>Lucas</surname>
              <given-names>A</given-names>
            </name>
            <collab>
              <named-content content-type="name">Higginson IJ</named-content>
            </collab>
            <collab>
              <named-content content-type="name">Sleeman KE</named-content>
            </collab>
          </person-group>
          <source>BMJ open</source>
          <article-title>Association of primary and community care services with emergency visits and hospital admissions at the end of life in people with cancer: a retrospective cohort study</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-cbc1adf3b413f02e6b16a46730dbeb65">
        <element-citation publication-type="journal">
          <issue>2</issue>
          <month>02</month>
          <page-range>204-212</page-range>
          <volume>51</volume>
          <year>2016</year>
          <pub-id pub-id-type="doi">10.1016/j.jpainsymman.2015.10.008</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Seow</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Barbera</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Pataky</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Lawson</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>O'Leary</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Fassbender</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>McGrail</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Burge</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Brouwers</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Sutradhar</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>Journal of Pain and Symptom Management</source>
          <article-title>Does Increasing Home Care Nursing Reduce Emergency Department Visits at the End of Life? A Population-Based Cohort Study of Cancer Decedents</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-619d1c1b4f83ddd4d70051e99eb67753">
        <element-citation publication-type="journal">
          <issue>5</issue>
          <month>05</month>
          <page-range>e725-e731</page-range>
          <volume>19</volume>
          <year>2023</year>
          <pub-id pub-id-type="doi">10.1200/OP.22.00307</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>Gajra</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Jeune-Smith</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Balanean</surname>
              <given-names>A</given-names>
            </name>
            <collab>
              <named-content content-type="name">Miller KA</named-content>
            </collab>
            <name>
              <surname>Bergman</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Showalter</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Page</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>JCO oncology practice</source>
          <article-title>Reducing Avoidable Emergency Visits and Hospitalizations With Patient Risk-Based Prescriptive Analytics: A Quality Improvement Project at an Oncology Care Model Practice</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-2110f48b381bc48fbf5b6cab63e8b620">
        <element-citation publication-type="journal">
          <fpage>318</fpage>
          <issue>30_suppl</issue>
          <volume>36</volume>
          <year>2018</year>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Patel KB</named-content>
            </collab>
            <name>
              <surname>Clinton </surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <source>J Clin Oncol</source>
          <article-title>Patient-centered cancer care (PCCC) as a roadmap to success in Alternate Payment Model (APM): A case study-based learning</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-f752ec27c21b05f46e4e54bb0c95a7f0">
        <element-citation publication-type="journal">
          <day>29</day>
          <issue>2</issue>
          <month>02</month>
          <page-range>pkae009</page-range>
          <volume>8</volume>
          <year>2024</year>
          <pub-id pub-id-type="doi">10.1093/jncics/pkae009</pub-id>
          <person-group person-group-type="author">
            <name>
              <surname>D'Avella</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Whooley</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>Milano</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Egleston</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Helstrom</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Patrick</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Edelman</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Bauman</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <source>JNCI cancer spectrum</source>
          <article-title>The impact of an oncology urgent care center on health-care utilization</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-9daf72317600c6b81aef0213527716ba">
        <element-citation publication-type="journal">
          <issue>3</issue>
          <month>03</month>
          <page-range>1225-1233</page-range>
          <volume>29</volume>
          <year>2021</year>
          <pub-id pub-id-type="doi">10.1007/s00520-020-05593-9</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Badger TA</named-content>
            </collab>
            <name>
              <surname>Sikorskii</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Segrin</surname>
              <given-names>C</given-names>
            </name>
            <collab>
              <named-content content-type="name">Given CW</named-content>
            </collab>
          </person-group>
          <source>Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer</source>
          <article-title>Supportive health education reduces health care utilization and costs in Latinas with breast cancer and their caregivers</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-b223433e1964da65641ae4e1c592dd55">
        <element-citation publication-type="journal">
          <fpage>16-16</fpage>
          <issue>1</issue>
          <volume>879</volume>
          <year>2021</year>
          <source>PharmacoEconomics Outcomes News</source>
          <article-title>Hospital-at-home oncology care may to save costs and resources in the USA</article-title>
        </element-citation>
      </ref>
      <ref id="journal-article-ref-3f5bfa82a63ac024a13d72c358df5544">
        <element-citation publication-type="journal">
          <issue>7_suppl</issue>
          <month>03</month>
          <page-range>4-4</page-range>
          <volume>34</volume>
          <year>2016</year>
          <pub-id pub-id-type="doi">10.1200/jco.2016.34.7_suppl.4</pub-id>
          <person-group person-group-type="author">
            <collab>
              <named-content content-type="name">Adelson KB</named-content>
            </collab>
            <name>
              <surname>Velji</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Patel</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Chaudhry</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Grizzle</surname>
              <given-names>S</given-names>
            </name>
            <collab>
              <named-content content-type="name">Lyons CA</named-content>
            </collab>
            <name>
              <surname>Lilenbaum</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>Journal of Clinical Oncology</source>
          <article-title>Understanding total cost of cancer care to determine strategic interventions to improve value.</article-title>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>