S M Nazmuz Sakib’s Microbiological Tumor Evolutionary Equation (MTEE): A Mathematical Framework for Understanding the Co-Evolution of Tumors and Microbiomes in Cancer Progression and Response to Therapy

Authors

  • S M Nazmuz Sakib Dhaka International University; Atlanta College of Liberal Arts and Sciences; School of Business And Trade; International MBA Institute; Harris University; Scholars Academic and Scientific Society, Bangladesh. https://orcid.org/0000-0001-9310-3014

DOI:

https://doi.org/10.31557/apjcn.2063.20251026

Keywords:

S M Nazmuz Sakib's Microbiological Tumor Evolutionary Equation, tumor-microbiome interaction, MTEE

Abstract

The two-way interaction between cancer and microbiome has attracted growing interest because of the possibility of its involvement in tumorigenesis, metastasis, and chemotherapy resistance. The co-evolution dynamics of tumors and microbiomes, however, and their impact on cancer biology, are unknown. This work presents S M Nazmuz Sakib’s Microbiological Tumor Evolutionary Equation (MTEE), a new mathematical model calculating the feedback processes between tumor cells and their related microbial communities. The MTEE applies evolutionary biology, microbial dynamics, and oncology to simulate how selective pressures of the tumor microenvironment mold microbial communities and consequently tumor growth and treatment response. By probing this evolutionary connection, the MTEE sheds light on the role of microbiomes in cancer development, metastasis, and treatment response. The platform further provides simulation of microbial therapies (e.g., probiotics, antibiotics, crafted microbiomes) to predict their effect on tumor phenotype and response to treatment. Finally, the MTEE is a perceptive tool for personalized cancer diagnosis and treatment, toward the goal of microbiome-guided interventions in cancer.

Author Biography

S M Nazmuz Sakib, Dhaka International University; Atlanta College of Liberal Arts and Sciences; School of Business And Trade; International MBA Institute; Harris University; Scholars Academic and Scientific Society, Bangladesh.

Prof. (H.C.) Engr. Dr. S M Nazmuz Sakib, CMSA®, FPWMP®, FTIP®, BIDA®, FMVA®, CBCA® is a Fellow at the Scholars Academic and Scientific Society, Member of International Association of Engineers - IAENG, a Bangladeshi Arena Grand Master (AGM) in FIDE (International Chess Federation), and a lifetime member of the Bangladesh English Language Teachers Association (BELTA). His educational journey began with the Primary School Certificate (PSC) from Cotton Research Station School in Sreepur, Gazipur, after which he studied Class 6 at Alhaz Dhanai Bepari Memorial (ADBM) High School in Sreepur before relocating to Jashore. He completed his Junior School Certificate (JSC) from Jagodishpur Mirzapur Ismail Secondary School in Jagodishpur, Chowgacha, Jashore, and his Secondary School Certificate (SSC) from A.K. High School and College, Dhania, Dhaka. He obtained his Higher Secondary Certificate (HSC) from Chowgacha Government College in Chowgacha, Jashore.
Engr. Sakib holds a Bachelor of Science in Business Studies (BSc) from the School of Business and Trade, an online business school in Switzerland, awarded in 2021 with a CGPA of 4.0 out of 4.0 (1st Class, 1st) and 97.06% marks. He also completed his Master of Business Administration (MBA) in Human Resources in 2023 from the International MBA Institute, an online business school in Switzerland. In addition, Dr. Sakib pursued a Bachelor of Laws (Honors) (LLB) at Dhaka International University, Dhaka, Bangladesh, graduating in 2023 with a CGPA of 3.31 out of 4, and a Bachelor of Engineering in Information Technology from Harris University in Liverpool, UK, in 2024 with a CGPA of 3.75 out of 4. He earned his Doctor of Business Administration (DBA) from Atlanta College of Liberal Arts and Sciences in 2025, graduating with A+ (Distinction).
Dr. Sakib got various Professional Certifications i.e. Unilever Digital Marketing Analyst, Unilever; AWS Cloud Solutions Architect, Amazon Web Services; Microsoft UX Design, Microsoft; Liberty Mutual Insurance Sales Agent, Liberty Mutual Insurance; Microsoft UX Design, Microsoft; Keller Williams Real Estate Agent, Keller Williams Realty, Inc.; HRCI Human Resource Associate, HRCI; SAS Statistical Business Analyst, SAS Education; Google Project Management, Google; Google Business Intelligence, Google; Google Digital Marketing and E-Commerce, Google; Google IT Support, Google; Google Data Analytics, Google; SAS Visual Business Analytics, SAS Education; Meta Social Media Marketing, Meta; Tally Bookkeeper, Tally BookkeeperTally Education Private Limited (TEPL); Strategy and Finance for the lifecycle of a Social Business, Yunus Social Business; Sustainability Analyst Fundamentals, Arizona State University; PepsiCo: Water Stewardship, PepsiCo; Business and Marketing Strategies, University of London; Data Exploration in Psychology, American Psychological Association & PsycLearn; American Politics, Foreign Policy, and US-India Ties, O.P. Jindal Global University; Modern and Contemporary Art and Design, MoMA The Museum of Modern Art; Digital Health, Imperial College London; Advanced Digital Transformation, IIM Ahmedabad; Qualitative Research Design and Methods for Public Health, Emory University; Qualitative Research Methods in Psychology, American Psychological Association & PsycLearn; Psychological Research, American Psychological Association & APA PsycLearn; Energy Production, Distribution & Safety, University at Buffalo & Stony Brook University; Project Management, University of Colorado Boulder; Introduction to Blockchain, American Institute of Certified Public Accountants (AICPA); Graphic Design, California Institute of the Arts; Managing Major Engineering Projects, University of Leeds; Recommender Systems, University of Minnesota; Six Sigma Yellow Belt, Kennesaw State University; AWS Fundamentals, Amazon Web Services; Engineering Project Management, Rice University; Autodesk Generative Design for Manufacturing, Autodesk; Project Management Principles and Practices, University of California, Irvine; Project Management & Other Tools for Career Development, University of California, Irvine; Six Sigma Green Belt, Kennesaw State University; Career Success, University of California, Irvine; Human Resource Management: HR for People Managers, University of Minnesota; Autodesk CAD/CAM/CAE for Mechanical Engineering, Autodesk.
Engr. Sakib's CPD Diploma Certifications include Advanced Diploma in Political Ideologies; Advanced Diploma in Tissue Engineering; Advanced Diploma in Genetic Engineering - Theory and Application; Diploma in Fashion Design; Diploma in Nutrition, Therapeutics and Health; Diploma in Biology; Diploma in Pharmacy Technician; Advanced Diploma in Soil Science and Technology; Diploma in Energy Economics, Energy Systems and Environmental Impact; Diploma in Community Psychology; Diploma in Training of Trainers; Advance Diploma in Principles of Industrial Engineering; Advanced Diploma in Production & Operation Management; Advanced Diploma in Modelling and Analytics for Supply Chain Management; Diploma in Effective Human Resource Administration; Diploma in Audio System Engineering; Diploma in ISO Standards, specialized - Integrated Management System (IMS); Diploma in Lean Manufacturing - Productive Management with Fundamental Tools; Advanced Diploma in Tourism and Hospitality Management; Diploma in Web Design; Diploma in Human Resources; and Diploma in Basic English Grammar.
Dr. Sakib's publications are A Novel Approach for Multi-cluster-Based River Flood Early Warning System Using Fuzzy-Logic-Based Learning and Rule Optimization, Applications of Fuzzy Logic in Decision Making and Management Science, Springer Nature; Group Revision is Better Than Self-Revision in Case of Mathematics, Vol. 3 No. 1 (2025): Noumerico, March 2025, Noumerico: Journal of Technology in Mathematics Education, Mathematics Education Department, Tribakti Lirboyo Islamic University; The 2003 US Intervention of Iraq: Objectives, Implications, and Global Security Dynamics, Handbook of Migration, International Relations and Security in Asia, Springer Nature; The Detrimental Impacts of Deforestation: Causes, Effects, and Potential Solutions, VOLUME: 06 ISSUE: 02, Journal of Natural and Applied Sciences of Pakistan, Kinnaird College for Women, Pakistan; Optimizing Beneficial Oral Hygiene Care: Transitioning from Manual Brushing and Utilizing Powered Toothbrushes to Improve Plaque Control and Prevent Gingival Inflammation, Update Dental College Journal, Update Dental College (UpDC), BD; Blockchain Technology for Smart Contracts, Blockchain Technology in the Automotive Industry, CRC Press, Taylor & Francis Group; Kinetics of Sodium Hydroxide and Ethyl Acetate Reaction in A Continuous Stirred Tank Reactor: A Comparison of Experimental and Theoretical Conversion, Volume 6 Issue 1 of Journal of Natural and Applied Sciences of Pakistan, Kinnaird College for Women, Pakistan; Evaluation of Three-Dimensional Reconstruction Technology in Precision Hepatectomy for Primary Liver Cancer, Formosan Journal of Surgery, Taiwan Surgical Association & Wolters Kluwer Health, Inc.; Internet of Medical Things (IoMT) for Remote Healthcare Monitoring Using Wearable Sensors, Vol 4 No 2 issue of International Journal of Computing and Related Technologies (IJCRT), Sindh Madressatul Islam University; Analysis of Fundamental Algebraic Concepts and Information Security System, Vol. 2 No. 1 (2024) of Noumerico: Journal of Technology in Mathematics Education, Mathematics Education Department, Tribakti Lirboyo Islamic University; Mathematical Models and Formulas for Language Development and Disorders: A Collection of Hypothetical and Novel Approaches, Childhood Developmental Language Disorders: Role of Inclusion, Families, and Professionals, IGI Global Scientific Publishing; Blockchain Technology for Smart Contracts: Enhancing Trust, Transparency, and Efficiency in Supply Chain Management, Achieving Secure and Transparent Supply Chains With Blockchain Technology, IGI Global Scientific Publishing; Salutogenic Marketing in the Elderly: Leveraging Digital Transformation in Geriatric Dentistry - Creating Positive and Meaningful Experiences for Older Adults, Geriatric Dentistry in the Age of Digital Technology, IGI Global Scientific Publishing; Fixed Point Theory and Insurance Loss Modeling: An Unlikely Pairing, Advancement in Business Analytics Tools for Higher Financial Performance, IGI Global Scientific Publishing; Navigating the New Frontier of Finance, Art, and Marketing: A Look at Cryptocurrencies, NFTs, and Metaverse, Concepts, Technologies, Challenges, and the Future of Web 3, IGI Global Scientific Publishing; Assessing enrichment and contamination of sediments in the effluent canal of the ore processing industry and Naviundu River in Lubumbashi, Democratic Republic of Congo, Vol. 58 (2023) of EQA (International Journal of Environmental Quality), Department of Agricultural and Food Sciences – Alma Mater Studiorum – University of Bologna; The Role of Innovation in Driving the Bioeconomy: The Challenges and Opportunities, Handbook of Research on Bioeconomy and Economic Ecosystems, IGI Global Scientific Publishing; Exploring the Intersection of Software Engineering and Mobile Technology from 2010 to 2021: A Review of Recent Research, Journal of Innovation Information Technology and Application (JINITA), Pusat Penelitian dan Pengabdian Masyarakat (P3M), Politeknik Negeri Cilacap (Cilacap State Polytechnic), Indonesia; Comparing the sociology of culture in Bangladesh and India: Similarities and differences in Bangladeshi and Indian cultures, Volume 6, Issue 1, June 2023, Simulacra, Center for Sociological Studies and Community Development, Department of Sociology, UNIVERSITAS TRUNOJOYO MADURA, Indonesia; Artificial Intelligence Model for Analyzing the Buying Patterns of Customers, Handbook of Research on AI and Machine Learning Applications in Customer Support and Analytics, IGI Global Scientific Publishing; Restaurant Sales Prediction Using Machine Learning, Handbook of Research on AI and Machine Learning Applications in Customer Support and Analytics, IGI Global Scientific Publishing; S M Nazmuz Sakib’s Hypothesis of Aerosol-Sea Ice Feedback: Implications for Climate System Dynamics, Asian Pacific Journal of Environment and Cancer, Asian Pacific Organization for Cancer Prevention; Assessing the Impact of Arctic Melting in the Predominantly Multilateral World System, Asian Pacific Journal of Environment and Cancer, Asian Pacific Organization for Cancer Prevention; ELECTROCHEMICAL WASTE WATER TREATMENT, Volume 10 and No. 1 (2022) archive, Waste Technology, Waste Resources Research Center (WRRC), Universitas Diponegoro; LiDAR Technology - An Overview, Jan2022, Vol. 15 Issue 1, p36-57, Volume 15 and Issue 1, IUP Journal of Electrical & Electronics Engineering, IUP Publications; The Impact of Oil and Gas Development on the Landscape and Surface in Nigeria, Asian Pacific Journal of Environment and Cancer, Asian Pacific Organization for Cancer Prevention.
Engr. Sakib's online courses include Webflow Animation, Forensic Psychology Basics in Russian, Grundlagen der Soziologie, Philosophy of Astro-Biology, Philosophy of Psychology, and several others published through Eduonix, BitDegree, Teachlr, and Udemy.

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Published

2025-10-26

How to Cite

Nazmuz Sakib, S. M. (2025). S M Nazmuz Sakib’s Microbiological Tumor Evolutionary Equation (MTEE): A Mathematical Framework for Understanding the Co-Evolution of Tumors and Microbiomes in Cancer Progression and Response to Therapy. Asian Pacific Journal of Cancer Nursing, 20251026. https://doi.org/10.31557/apjcn.2063.20251026

Issue

Asian Pacific Journal of Cancer Nursing

Section

Perspectives and View Points