A Fingerprint of miRNA-93 in Cancer Progression and Therapeutic Targets

Abstract

MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) that can greatly influence cellular activity by interacting with mRNAs either individually or through RISC. This wide range of activity shown by miRNAs makes them highly sensitive, and any dysfunction on their part can cause many diseases, including cancer. MiR-93 is one such miRNA that has been found to be associated with various types of cancers, including hepatocellular carcinoma, breast cancer, gastric cancer, and lung cancer. This review article focuses on the role played by miR-93 in several common cancers to shed more light on miRNA and its association with cancer. The article discusses the oncogenic or tumour-suppressing function of miR-93 in different types of cancers and elucidates the various pathways through which miR-93 exerts its oncogenic or tumour-suppressing activities. The article also highlights potential therapeutic targets that can be developed based on the understanding of the underlying mechanism of cancer and the role of miRNAs in this disease.