Long non-coding RNA Panel on Prognosis of Glioma in Iranian Patients

Authors

  • Sara Esmaeili Department of Genetics, University of Social Welfare and Rehabilitation, Sciences, Tehran, Iran.
  • Mahsa Kazerani Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
  • Elham Arjmandrad Department of Molecular and Cellular Sciences, Faculity of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Amin Pourzarin Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Alimohammad Falahati Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  • Amin Khosravani Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Abdolazim Sarli Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Hasan Ashoori Human Genetics center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

DOI:

https://doi.org/10.31557/apjcb.2023.8.3.231-234

Keywords:

giloma, cancer, lncRNA

Abstract

Objective: Glioma is one of the most malignant brain tumors, accounting for about half of the gliomas that occur in central nervous system (CNS), originates from the glial tissue of the brain. The aim of the present study was to determine the expression levels of 3 lncRNAs (AGAP2-AS1, LINC01446 and HOTAIRM1) in patients with high grade glioma in comparison with low grade glioma.
Methods: Case group consisted of 70 high grade glioma patients control group consisted of 70 patients affected with low grade glioma. RNA extraction was performed using a RNA extraction kit.
Result: Our results showed that the expression of AGAP2-AS1 and LINC01446 genes significantly increased with increasing tumor grade (with fold-change ratio of 2.1 and 3.8 respectively). Also the expression of HOTAIRM1 gene increased with increasing tumor grade but this increase was not statistically significant (P value=0.6).
Conclusion: We concluded that AGAP2-AS1 and LINC01446 are promising lncRNA markers in prognosis of glioma.

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Published

2023-09-20

How to Cite

1.
Esmaeili S, Kazerani M, Arjmandrad E, Pourzarin A, Falahati A, Khosravani A, et al. Long non-coding RNA Panel on Prognosis of Glioma in Iranian Patients. Asian Pac J Cancer Biol [Internet]. 2023 Sep. 20 [cited 2026 Jun. 4];8(3):231-4. Available from: http://waocp.com/journal/index.php/apjcb/article/view/1108

Issue

Vol. 8 No. 3 (2023)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).