Differences in Nasopharyngeal and Lung Histopathology in Wistar Rats (Rattus norvegicus) Given Inhaled Formaldehyde Exposure with Doses of 20, 30, and 40 ppm

Authors

  • Anak Agung Ayu Niti Wedayani Pharmacology Department, Faculty of Medicine, Mataram University, Indonesia.
  • Abdul Qadar Punagi Ear, Nose, Throat Department, Faculty of Medicine, Hasanuddin University, Indonesia.
  • Nova Audrey Ear, Nose, Throat Department, Faculty of Medicine, Hasanuddin University, Indonesia.
  • Husni Cangara Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Indonesia.
  • David Giffard Kawi Junior Faculty of Medicine, Mataram University, Indonesia.
  • Ricky Setiadi Yusuf Faculty of Medicine, Mataram University, Indonesia. https://orcid.org/0000-0002-2062-7682

DOI:

https://doi.org/10.31557/apjcb.2023.8.4.335-338

Keywords:

Nasopharynx, Lung, Dysplasia, Histopathology, Formaldehyde

Abstract

Background: Formaldehyde is known as a chemical substance that may induce structural cell changes in several organs, especially the respiratory system. Different concentrations of exposure may result in different degrees of severity in histopathology.

Materials and Methods: Twenty male Wistar rats were divided into 4 groups. Inhalation of 10% formaldehyde exposure for 6 hours per day over 16 weeks was conducted. Nasopharyngeal and lung tissues were collected and stained with hematoxylin-eosin (H&E) to observe histopathological structural changes and assess the degree of severity. Bivariate analysis was performed to calculate correlation coefficients.

Results: This experimental study found that severe dysplasia is correlated with prolonged exposure. A strong correlation was found between formaldehyde concentrations and dysplasia (r=0.682), and a moderate correlation between duration of exposure and dysplasia (r=0.488).

Conclusion: The severity of dysplasia in rats aligns with both the duration and concentrations of formaldehyde exposure. Prolonged exposure increases the severity of dysplasia, as does exposure to higher concentrations of formaldehyde.

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Published

2023-10-21

How to Cite

1.
Niti Wedayani AAA, Qadar Punagi A, Audrey N, Cangara H, Kawi Junior DG, Yusuf RS. Differences in Nasopharyngeal and Lung Histopathology in Wistar Rats (Rattus norvegicus) Given Inhaled Formaldehyde Exposure with Doses of 20, 30, and 40 ppm. Asian Pac J Cancer Biol [Internet]. 2023 Oct. 21 [cited 2026 Jun. 4];8(4):335-8. Available from: http://waocp.com/journal/index.php/apjcb/article/view/1232

Issue

Vol. 8 No. 4 (2023)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).