Biomarkers for Early Detection of Ovarian Cancer: A Review

Authors

  • Devarajappa Gari Bindu Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.
  • Kopparapu Venkata Nanda Kumar Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.
  • Kasireddy Likitha Reddy Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.
  • Mekala Siva Charani Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.
  • Yaraganti Gowthami Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.

DOI:

https://doi.org/10.31557/apjcb.2024.9.1.81-85

Keywords:

Early detection, Biomarkers, CA125, HE4, microRNAs, mesothelin.

Abstract

Ovarian cancer, with its asymptomatic early stages, poses a significant challenge for early diagnosis and survival improvement. The utilization of tumor markers, including CA -125 and HE4 has become crucial in detecting these silent killers. Additionally, gene-based markers like BRCA1 and BRCA2 mutations are increasingly acknowledged for indicating ovarian cancer susceptibility. Promising emerging biomarkers, such as microRNAs and circulating tumor cells, offer new research avenues and diagnostic possibilities for the early detection of ovarian cancer. This article provides a comprehensive review of current specific markers, gene-based indicators, emerging markers, and other notable approaches in the early identification of ovarian cancer.

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Published

2024-01-09

How to Cite

1.
Gari Bindu D, Nanda Kumar KV, Likitha Reddy K, Siva Charani M, Gowthami Y. Biomarkers for Early Detection of Ovarian Cancer: A Review. Asian Pac J Cancer Biol [Internet]. 2024 Jan. 9 [cited 2026 Jun. 11];9(1):81-5. Available from: http://waocp.com/journal/index.php/apjcb/article/view/1265

Issue

Vol. 9 No. 1 (2024)

Section

Systematic Review and Meta-analysis:

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).