The Application of Polybutyl Cyanoacrylate (PBCA) Nanoparticles in Delivering Cancer Drugs

Authors

  • Vahid Salehi Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.
  • Mohaddeseh Izadkhah Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.
  • Hanifeh Salehi Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.
  • Niki Sadeghi Pour Jam General Hospital Tehran, Iran.
  • Parizad Ghanbarikondori Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.

DOI:

https://doi.org/10.31557/apjcb.2024.9.2.209-218

Keywords:

Drug resistance, Drug delivery, Cancer, Nanoparticle, Poly butyl cyanoacrylate

Abstract

Background: Cancer remains a significant global health challenge, accounting for one in eight deaths worldwide. Chemotherapy, the primary cancer treatment, is often limited by drug resistance. Optimizing therapy procedures has been suggested to improve survival and quality of life for cancer patients, including those with drug resistance. In recent years, nanotechnology has garnered significant attention for its potential in cancer treatment. Nanoparticles (NPs) are widely utilized to enhance therapeutic outcomes by improving drug bioavailability, solubility, and retention time. NPs offer essential conditions for targeted drug delivery through various delivery systems, including microcapsules or NPs. Polybutyl cyanoacrylate (PBCA) is among the most commonly used carriers for drug delivery in cancer treatment, with several studies investigating its efficacy.

Methods: This article aims to review the effectiveness of PBCA as a drug delivery system in the treatment of various cancers.

Results: Several studies have utilized PBCA for drug delivery in cancer treatment, indicating its potential efficacy in this regard.

Conclusion: The review highlights the potential of PBCA as a promising drug delivery system for the treatment of different types of cancer.

Downloads

Published

2024-05-26

How to Cite

1.
Salehi V, Izadkhah M, Salehi H, Sadeghi Pour N, Ghanbarikondori P. The Application of Polybutyl Cyanoacrylate (PBCA) Nanoparticles in Delivering Cancer Drugs. Asian Pac J Cancer Biol [Internet]. 2024 May 26 [cited 2026 Jun. 11];9(2):209-18. Available from: http://waocp.com/journal/index.php/apjcb/article/view/1410

Issue

Vol. 9 No. 2 (2024)

Section

Systematic Review and Meta-analysis:

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).