The Application of Polybutyl Cyanoacrylate (PBCA) Nanoparticles in Delivering Cancer Drugs

  1. Vahid Salehi ,
  2. Mohaddeseh Izadkhah ,
  3. Hanifeh Salehi ,
  4. Niki Sadeghi Pour ,
  5. Parizad Ghanbarikondori

Vol 9 No 2 (2024)

DOI 10.31557/apjcb.2024.9.2.209-218


Overview: Cancer remains a significant global health challenge, accounting for one in eight deaths worldwide. Chemotherapy, the primary cancer treatment, is often limited by drug resistance. Optimizing therapy procedures has been suggested to improve survival and quality of life for cancer patients, including those with drug resistance. In recent years, nanotechnology has garnered significant attention for its potential in cancer treatment. Nanoparticles (NPs) are widely utilized to enhance therapeutic outcomes by improving drug bioavailability, solubility, and retention time. NPs offer essential conditions for targeted drug delivery through various delivery systems, including microcapsules or NPs. Polybutyl cyanoacrylate (PBCA) is among the most commonly used carriers for drug delivery in cancer treatment, with several studies investigating its efficacy.

Methods: This article aims to review the effectiveness of PBCA as a drug delivery system in the treatment of various cancers.

Results: Several studies have utilized PBCA for drug delivery in cancer treatment, indicating its potential efficacy in this regard.

Conclusion: The review highlights the potential of PBCA as a promising drug delivery system for the treatment of different types of cancer.


Advances in technology and knowledge across diverse industries are fueling initiatives to improve operational excellence and product performance. Service-oriented businesses are working to enhance their delivery and performance standards while manufacturing sectors are prioritizing the enhancement of product quality. In the electronics industry, substantial resources are being allocated to prolong product lifespans, leading to the development of more dependable and capable devices. Likewise, significant strides are being made in the healthcare, dentistry and medical sectors to refine treatments and uncover cures for various diseases [1-23]. Today, cancer remains a significant health challenge, contributing to a high number of fatalities [24]. According to the World Economic Forum in 2011, approximately 13.3 million new cancer cases were projected for the year 2010, amounting to an estimated cost of US$ 290 billion.

However, these costs are anticipated to rise and reach a staggering US$ 458 billion by 2030 [25]. Cancer refers to the uncontrolled multiplication and proliferation of irregular cells within the body [25]. More than 200 distinct types of cancer are known to affect humans [25]. More than 200 distinct types of cancer are known to affect humans [26]. Environmental elements have been implicated in contributing to 80-90% of cancer cases [27]. In contrast, hereditary factors have been linked to merely 3-10% of cancer instances [26]. Chemotherapy is recognized as a primary method for treating cancer; however, its efficacy is constrained by drug resistance [28]. This issue is particularly prevalent in patients with metastatic tumors. Lu et al., (2016) categorized chemotherapy resistance into two groups - inherent and acquired. The researchers suggest that innate resistance may stem from intratumoral heterogeneity [28]. Acquired resistance arises due to genetic and epigenetic modifications, leading to alterations in drug sensitivity [29]. Traditional chemotherapeutic drugs are indiscriminately distributed throughout the body, affecting both malignant and healthy cells alike, thereby restricting their usage owing to heightened toxicity levels [30]. Despite advancements in chemotherapy extending patient survival over the past 25 years, alternative methods are necessary given its limitations. Consequently, research fields have progressed to develop novel approaches like targeting blood vessels that supply tumors and utilizing targeted therapeutics [31]. Currently, nanotechnology is widely implemented across various uses, notably in medical therapeutics [32]. With respect to nanotechnology, nanoparticles (NPs) are increasingly utilized to enhance therapeutic effectiveness by increasing bioavailability, solubility, and duration in the system [33]. By employing nanoparticle-drug formulations, there is potential to decrease healthcare expenses for patients and lessen associated toxicities [34]. Tracing back to the 1980s, nano-medicine emerged as a promising field, with nano-encapsulation being instrumental in enhancing drug efficacy, specificity, safety, and overall potency [35].Nano-medicinal interventions offer multiple benefits, encompassing heightened interactions with the biological milieu, elevated uptake into designated tissues, boosted absorbance rates, prolonged retention periods, and augmented intracellular permeability [36]. The design of nano-medicinal formulations heavily depends on selecting appropriate polymeric frameworks that provide optimal encapsulation capabilities, enhanced bioavailability, and extended retention durations [37]. The dimensions and distribution patterns of nanoparticles (NPs) play significant roles in determining their impact on cell membranes and penetrative abilities in physiological drug obstacles. Investigations indicate that tailoring the particle size based on the intended tissue or target site and considerations regarding circulatory conditions yields favorable results [31]. Polybutylcyanoacrylate (PBCA) nanocarriers boast desirable attributes such as diminutive sizing, straightforward manufacturing, scalability, effortless purification processes, excellent in vitro stability, and swift removal from the body [38]. PBCA NPs demonstrate capacity to mitigate cisplatin’s instability issues, indicating their potential role in facilitating cancer treatments [39]. Ebrahimi Shahmabadi et al. [40] highlighted PBCA’s advantageous traits for delivering cisplatin in glioblastoma, namely enhanced stability and gradual release. These nanoparticles can be fabricated using either anionic polymerization reactions or miniemulsion polymerization techniques. Additional investigations conducted in controlled environments revealed that the miniemulsion polymerization approach proved effective for producing Cisplatin-loaded PBCA nanoparticles specifically designed for treating ovarian cancer [41]. Previous research findings indicated that emulsion polymerization might not be an ideal solution for incorporating medications into PBCA NPs, instead recommending alternatives such as miniemulsion polymerization for this purpose [42].

Which PBCA production technique is best suited for pharmaceutical transport? How proficient is chosen PBCA modality at addressing certain forms of cancer? Hence, this investigation aims to assess the performance of selected nanoparticles against diverse neoplastic diseases.

Overview of techniques employed for generating polymer- based nanoparticles

The most common method for creating drug-containing poly(butyl cyanoacrylate) nanoparticles (PBCA NPs) is to introduce the drug during the emulsification process or when it adheres to the surface of the NPs. This approach is often utilized due to its simplicity and effectiveness in loading drugs onto PBCA NPs [43-44]. The carrier’s capacity can be enhanced through certain production elements such as using a stabilizer, regulating the pH of the mixture, and controlling the quantity and duration of drug addiction. Additionally, modifying the compatibility between the drug and the nano-particle material using adjustable water-loving (hydrophilic) or water-repelling (hydrophobic) qualities of poly(BCAco-OCA) can promote drug loading and encapsulation effectiveness [45]. Most of the trapped medication’s mass by PBCA NPs is constrained due to the drug’s solubility in the reaction medium [46-48]. Over recent years, there has been significant growth in the application scope of polymer NP surface areas, which have become increasingly important across numerous industries, ranging from medicine and biotechnology to pollution management and environmental science. Presenting an explanation for what NPs stand for is essential. In essence, NPs refer to tiny, particulate substances measuring between 10 and 1000 nanometers in diameter, characterized by their solid state and colloidal nature [49]. Initially, NP manufacturing techniques originated from the discipline of latex engineering established by polymer chemists. This was based upon in situ polymerization of monomers across varying media types. Early pioneers synthesized initial NPs utilized for medicinal purposes via polymerization processes back in the 1970s. Known as vesicular structures called “nanocapsules,” they functioned similarly to reservoirs where enclosed materials were confined within fluid cores - either oily or aquatic - encircled by robust outer layers made up of solid materials [50]. A schematic imagine of polymer NPs is presented in Figure 1.

Figure 1. A Schematic of Polymer NPs (a), Nanocapsules Having Oil (b) and Nanocapsules Having Water (c).

Two widely recognized polymerization approaches include dispersion polymerization and emulsion polymerization. With regard to dispersion polymerization, this technique utilizes three primary components: an initiator, monomer, and solvent. Herein, the freshly formed polymer functions as its own dispersant or stabilizing agent during the process [51]. Through the course of dispersion polymerization, polymers come into existence within the uninterrupted stage before subsequently crystallizing out right into novel separate particle phases. These emergent entities get steadied thanks to the presence of polymeric agents acting as stabilizers [51]. Dispersion polymerization hinges on the concept wherein the monomer is diffused or dissolved in an aquatic setting. Emulsion polymerization constitutes another approach whereby the monomer becomes suspended in a non-solvent containing surfactants mixture leading towards formation of swelled microscopic particles plus stable monomer drops. Such reactions proceed given presence of catalysts. Emulsion Polymerizations fall under two categories, namely those occurring organically within a constant medium versus other instances taking place aqueously likewise [51]. Given that PBCA is customarily formulated employing miniemulsion and anionic polymerization tactics, the focus shall rest solely on said strategies. Research efforts recounting the conception of taxane-imbued PBCA NPs leveraging mini-emulsion protocols or anionic polymerization have indeed emerged previously [52-53].

Miniemulsion commonly acknowledged strategy to generate diminutive, enduring particles nested in an unbroken surrounding medium via high sheer force implementation [54]. Droplet dimensions predominantly depend on specific emulsifiers’ identity and employed quantities in respective configurations. Mini-emulsion polymerization triggers polymerization initiation inside tinier, secured droplets instead - essentially meaning that polymerization events occur within diminutive nanoscale capsules. To facilitate direct miniemulsions, researchers often incorporate long-chain alkanes functioning as auxiliary stabilizers during oil-in-water settings. Figure 2 provides schematic overview covering direct mode of miniemulsion polymerization sequence embracing dispersement of oil portions through water-based platforms [55].

Figure 2. The Process of Direct (oil-in-water) Miniemulsion Polymerization, Adopted from Landfester and Musyanovych, (2010).

Contrasting emulsion polymerization, this tactic doesn’t mandate migration of monomers nor additional hydrophobic molecules from original tanks into designated sites meant for polymerization responses [56]. Owing to this, miniemulsion polymerization might reasonably merit recognition as some sort of single-stage nano-encasement operation, especially tailored towards effective sequestration of hydrophobic substances [57]. Nearly all poly (alkylcyanoacrylate) nanoassemblages originate fruitful results after capitalizing on anionic polymerization techniques [58]. Cyanoacrylic acid derivatives undergo in-situ synthesis while steeped in aqueous environments through means of anionic polymerization. One notable example includes suspending butyl cyanoacrylate monomer within aquatic domains, consequently generating discrete particles [41]. Depiction of anionic polymerization response featured in Figure 3.

Figure 3. Anionic Polymerization of Alkyl Cyanoacrylate Monomers Forming of NPs. Hydroxyl ions in water are starting the reaction.

Demonstrated capability exists regarding encasement of double-stranded DNA filaments into PBCA nanostructures enabled via anionic polymerization, implicating active engagement between miniemulsion droplets plus neighboring steady domain [59].

Utilizing Poly(butyl cyanoacrylate) (PBCA) as a drug carrier system for cancer treatment

In this study, we explore the use of Poly(butyl cyanoacrylate) (PBCA) as a delivery vehicle for diverse medications via multiple techniques. We will delve into each method’s mechanics and examine the pharmaceuticals being transported.

Using PBCA in ovarian cancer

Paclitaxel proves to be an effective antineoplastic agent against several forms of cancer, most notably demonstrating remarkable success in treating ovarian cancer [60]. The commercial version of this product encounters significant difficulties due to its inadequate solubility in water [61]. Furthermore, research indicates that one possible outcome of overcoming multi-drug resistance (MDR) could be the absorption of nanoparticles (NPs) onto the surface of cells [62]. Earlier investigations have disclosed techniques for producing paclitaxel-infused PBCA nanoparticles either via miniemulsion processes or anionic polymerization methods [52]. According to a study by Ren and colleagues in 2011 [63], paclitaxel-filled PBCA nanoparticles were developed using the interfacial polymerization technique to examine their potential in mitigating MDR in human ovarian resistant cells (A2780/T) and explore their underlying mechanisms. The resulting NPs had a spherical shape with an average size of 224.5±5.7 nm. The findings suggested that these NPs enhanced cytotoxicity and relieved MDR by hindering the activity of P-glycoprotein induced by the NP system. Additionally, they found that interfacial polymerization resulted in higher encapsulation and drug loading efficiency than emulsion polymerization, attributed to the inclusion of surfactants like lecithin and dextran 70. Another investigation explored the toxic impact of Cisplatin-filled PBCA NPs on the Cisplatin-resistant ovarian cancer cell line A2780cp [41]. Cisplatin is a primary medication for treating ovarian cancer due to its mechanism of attaching to DNA and triggering apoptosis. Researchers created nanoparticles (NPs) via the miniemulsion polymerization technique. The NPs’ dimensions, size distribution, and zeta potential were measured at 489 nanometers, 0.429, and -20 millivolts, respectively. This research proposes enhanced effectiveness of Cisplatin-PBCA NPs and recommends further examination with in vivo experiments related to ovarian cancer. Kanaani et al. (2017) recently examined the fundamental attributes and cytotoxic consequences of nano-poly (butyl cyanoacrylate) containing carboplatin on ovarian cancer cells. They developed non-PEGylated and PEGylated NPs utilizing the mini-emulsion polymerization method for PBCA NPs. Both formulation’s cytotoxicity was tested on the A2780CIS ovarian cancer cell line following various time intervals of 24, 48, and 72 hours. According to the cytotoxicity outcomes, both forms of nano-drugs demonstrated higher toxicity compared to the unbound drug. Furthermore, this study suggests that PBCA NPs could serve as promising options for nano-drug development in chemotherapy. Conclusively, these scientists determined that both PEGylated and non-PEGylated PBCA NPs function well as carriers for delivering carboplatin to the ovarian cancer cell line A2780CIS [56].

Using PBCA in gastric cancer

Magnetic targeting medication is considered the latest type of targeted treatments, offering advantages over other types of medications due to its reduced absorption by the reticuloendothelial system (also known as RES). This unique feature sets it apart from previous generations of targeted therapies [64]. The widely recognized challenge in treating solid tumors involves the creation and delivery of magnetic-responsive carriers capable of being administered via intravenous injection and reaching any desired location within the body’s systems. Successful implementation of such a method could significantly improve cancer therapy outcomes [65]. Past investigations examined the impact of aclacinomycin A-infused magnetic polybutylcyanoacrylate NPs on stomach tumor progression using both in vivo and in vitro methods. To do this, they created magnetic PBCA spheres containing aclacinomycin A via interface polymerization. Before starting treatment, magnets (with strength of 2.5 Tesla) were positioned inside the tumor tissues for each mouse. Encapsulation of aclacinomycin A within these magnetic PBCA spheres resulted in a content level of 12.0% and an average particle size of 210 nanometers. Inhibition rates of free aclacinomycin A (at dose of 8mg per kilogram of body mass), high-dose magnetic PBCA spheres loaded with aclacinomycin A (8mg/kg bm), low-dose magnetic PBCA spheres carrying aclacinomycin A (1.6mg/kg bm) and plain magnetic PBCA spheres on human stomach cancer in nude mice were measured at 22.63%, 52.55%, 30.66% and 10.22%, respectively. Researchers determined that magnetic- guided chemotherapy utilizing aclacinomycin A-laden magnetic PBCA spheres exhibited enhanced tumor targeting, improved effectiveness, and decreased toxicity compared to conventional approaches.

Applying PBCA in breast cancer

According to Li et al. (2015), there is a notable impact of Cisplatin, when enclosed in dextran Nanoparticles (NPs), on suppressing breast cancer. Research has indicated that the effectiveness of Cisplatin can be enhanced through its combination with different types of NPs [66]. In their study, Farhat et al., (2009) evaluated the potential of Lipoplatin as a therapy for HER2/neu negative metastatic breast cancer and concluded that using liposomal Cisplatin alongside vinorelbine may result in promising activity and well-tolerated outcomes as an initial treatment option for this particular form of cancer [67]. Koohi Moftakhari Esfahani et al. (2016) investigated the usefulness of Cisplatin-infused PBCA NPs in managing breast cancer utilizing an orthotopic model of the disease. The researchers created these Cisplatin-laden PBCA NPs via a miniemulsion polymerization technique. Their findings suggested that employing Cisplatin-loaded PBCA NPs might improve the drug’s efficiency while simultaneously reducing its adverse effects [38]. Cabeza et al. (2015) examined the anti-tumor properties of doxorubicin in treating breast cancer by incorporating it into PBCA-NPs. These NPs were fabricated using the emulsion/polymerization method. Based on their results, they proposed that the heightened anti-tumor activity of doxorubicin-loaded PBCA-NPs could allow for a reduced dosage of doxorubicin necessary to produce an adequate therapeutic response while minimizing toxic side effects [68].

Applying PBCA in prostate cancer

A research project was carried out to examine how prostate cancer cells absorb and distribute PBCA- encapsulated Nile Red or free Nile Red in the culture media [69]. The researchers used flow cytometry and confocal laser scanning microscopy to analyze the uptake and intracellular localization. According to their findings, direct delivery of anticancer medicines to intracellular target molecules via a contact-mediated approach was not successful. However, they suggested that using a contact-based transfer method and higher uptake of encapsulated medications over non-encapsulated ones may aid in delivering hydrophobic anticancer treatments, improving cancer therapy.

Applying PBCA in glioblastoma cancer

Glioblastoma is identified as one of the most invasive forms of cancer in humans. Due to its location within the brain, it’s challenging to treat this type of cancer because drugs need to cross the blood-brain barrier (BBB) first. A research team led by Ebrahimi Shahmabadi et al. [40] carried out a study to evaluate how well cisplatin-loaded Polybutylcyanoacrylate nanoparticles (PBCA NPs) perform against glioblastoma. They synthesized these nanoparticles using the miniemulsion polymerization technique and added a layer of polysorbate 80 to help them penetrate the BBB in rats with glioblastomas. Their results showed that while nanodrugs had lower effectiveness compared to free drugs, they also reduced harmful side effects associated with traditional treatments, suggesting potential benefits when applied to different types of tumors. However, modifications like adjusting particle size or altering their surfaces could improve successful penetration through the BBB.

Applying PBCA in brain cancer

Considers have combined PBCA with the nonionic surfactant polysorbate-80 and found fitting conveyance of an assortment of little polar drugs into the central apprehensive framework (CNS) in numerous considers [70, 71]. Drugs including doxorubicin, loperamide, tubocurarine, and dalargin were adsorbed onto PBCA-NPs and targeted to the CNS, where their pharmacological effects were found [72]. PBCA-NP did not produce nonspecific disruption of the BBB. Studies have proposed an alternative to the uptake of PBCA-NPs in the brain, whereby NPs induce nonspecific permeation of the BBB [73]. PBCA-NPs have been reported to be capable of delivering drugs as BBB-impermeable fluorophores of various sizes, from 500 Da target polar molecules to 150,000 Da tagged immunoglobulins in live mouse brains [74]. However, high doses of PBCA-NP with polysorbate-80 may damage the BBB. Studies have reported that PBCA-NP only has pharmacological effects after drug administration. It has been shown that polysorbate 80 can adsorb plasma apolipoprotein E (Apo-E) and Apo-E coated NPs through the LDL uptake system [75]. Research involving rat subjects examined polysorbate 80-covered poly-lactic-co-glycolic acid nanoparticles that contained methotrexate-transferrin. The findings suggested improved tissue entry, reduced organ harmfulness, and enhanced tumor-fighting abilities compared to untargeted NPs [76]. According to Kreuter and Gelperina (2008), NPs covered with polysorbate 80 or poloxamer 188 demonstrated successful transportation of doxorubicin past the blood-brain barrier (BBB) and decreased medication toxicity [77]. In contrast, magnetic NPs were noted by Laurent et al. (2012) and Mahmoudi et al. (2011) as particularly effective for enhancing BBB permeability due to heightened sensitivity among brain cells relative to those found in the liver and heart. This suggests that magnetic NPs may be an optimal choice for drug delivery within the central nervous system [78, 79]. Reimold et al. [80] assessed NP distribution to the brain using fluorescence microscopy. They employed a novel miniemulsion technique to create PBCA particles, which exhibited high yields and consistent production. These NPs encapsulated either FITC-dextran, rhodamine-123, or doxorubicin at varying concentrations and were then coated with polysorbate 80 prior to injection into rats. Results revealed that surface-modified PBCA-NPs successfully crossed the BBB and functioned as a vehicle for drug administration to the central nervous system (CNS). Consequently, it was determined that colloidal polymeric structures offered a promising method for overcoming the BBB challenge. Tian et al. [81] investigated the efficacy of polysorbate- 80-covered PBCA-NPs for administering medications to animal brains. Utilizing emulsion polymerization techniques, they synthesized these NPs containing temozolomide and observed elevated levels within the brain when utilizing polysorbate-80-coated PBCA-NPs versus unbound medication. Thus, their research supports the potential use of polysorbate-80-coated PBCA-NPs as a suitable carrier for temozolomide delivery to the brain.

In conclusion, mankind has made remarkable progress in several disciplines by leveraging insights from both physical and mental health conditions. This interdisciplinary approach has led to advancements in areas like medicine, dentistry, chemistry, biochemistry, psychology, electrical engineering, environmental science, nanotechnology, nutrition, and many others. Consequently, our understanding and capabilities in these domains have improved significantly, leading to enhanced productivity and better quality of life [82-93] [82, 95-112].

The objective of this review paper was to examine research investigating the use of the PBCA technique in drug delivery across various types of cancer. While the PBCA process has been extensively implemented in certain malignancies, it is currently being studied in others. Therefore, drawing definitive conclusions about the efficacy of the PBCA approach for drug delivery is challenging. Nevertheless, many studies have indicated positive outcomes associated with using the PBCA method for effective drug delivery. Concerning the preparation method, it appears that miniemulsion is well-suited for this purpose. Furthermore, there is evidence suggesting that the PBCA technique may be particularly useful in treating brain cancer. Further investigation is recommended to fully establish the effectiveness of the PBCA procedure.


  1. The Correlations of Scene Complexity, Workload, Presence, and Cybersickness in a Task-Based VR Game Sanaei M, Gilbert SB , Javadpour N, Sabouni H, Dorneich MC , Kelly JW . 2024. CrossRef
  2. Cybersickness Detection through Head Movement Patterns: A Promising Approach Salehi M, Javadpour N, Beisner B, Sanaei M, Gilbert SB . 2024. CrossRef
  3. Preparation, Characterization and Cytotoxic Studies of Cisplatin-containing Nanoliposomes on Breast Cancer Cell Lines Mohammadinezhad F, Talebi A, Allahyartorkaman M, Nahavandi R, Vesal M, Khiyavi AA , Velisdeh ZJ , et al . Asian Pacific Journal of Cancer Biology.2023;8(2). CrossRef
  4. Improving the Efficacy of Cisplatin using Niosome Nanoparticles Against Human Breast Cancer Cell Line BT-20 : An In Vitro Study Kanaani L, Mazloumi Tabrizi M, Akbarzadeh A, Javadi I. Asian Pacific Journal of Cancer Biology.2017;2. CrossRef
  5. Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation Roudsari MH , Saeidi N, Kabiri N, Ahmadi A, Tabrizi MM , Shahmabadi HE , Khiyavi AA , Reghbati B. Asian Pacific Journal of Cancer Biology.2016;1(1). CrossRef
  6. The Effect of Curcumin in Combination Chemotherapy with 5-FU on non-Malignant Fibroblast Cells Sarkhosh H, Mahmoudi R, Malekpour M, Ahmadi Z, Khiyavi AA . Asian Pacific Journal of Cancer Care.2019;4(1). CrossRef
  7. Reliability Characterization of Solder Joints in Electronic Systems Through a Neural Network Aided Approach Reihanisaransari R, Samadifam F, Salameh AA , Mohammadiazar F, Amiri N, Channumsin S. IEEE Access.2022;10. CrossRef
  8. Plasma Therapy for Medication-Related Osteonecrosis of the Jaws- A Case Report Sadrabad MJ , Saberian E. Case Reports in Clinical Practice.2023;8(1). CrossRef
  9. The effect of dentin matrix proteins on differentiation of autologous guinea pig dental pulp stem cells Taher A, Sadrabad M, Izadi A, Ghorbani R, Sohanian S, Saberian E. Journal of the Scientific Society.2023;50. CrossRef
  10. Explore the most recent advancements in the domain of self-healing intelligent composites specifically designed for use in dentistry Tavasolikejani S, Farazin A. Journal of the Mechanical Behavior of Biomedical Materials.2023;147. CrossRef
  11. Clinical efficacy of LLLT in treatment of trigeminal neuralgia – Case report Jalili Sadrabad M, Pedram A, Saberian E, Emami R. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2023;35(6). CrossRef
  12. Oral cancer at a Glance Saberian Elham, Jenca Andrej, Petrášová Adriána, jencova janka, jahromi reza, seiffadini rahman. 2023. CrossRef
  13. Fabrication and modeling of nanocomposites with bioceramic nanoparticles for rapid wound healing: An experimental and molecular dynamics investigation Tavasolikejani S, Farazin A. Nanomedicine Research Journal.2023;8(4). CrossRef
  14. The effect of increasing temperature on simulated nanocomposites reinforced with SWBNNs and its effect on characteristics related to mechanics and the physical attributes using the MDs approach Tavasolikejani S, Farazin A. Heliyon.2023;9(10). CrossRef
  15. Copper nanoparticles embedded into nitrogen-doped carbon fiber felt as recyclable catalyst for benzene oxidation under mild conditions Tavasolikejani S, Hosseini SM , Ghiaci M, Vangijzegem T, Laurent S. Molecular Catalysis.2024;553. CrossRef
  16. Preparation, characterization, and cytotoxic effects of liposomal nanoparticles containing cisplatin: an in vitro study Poy D, Akbarzadeh A, Ebrahimi Shahmabadi H, Ebrahimifar M, Farhangi A, Farahnak Zarabi M, Akbari A, Saffari Z, Siami F. Chemical Biology & Drug Design.2016;88(4). CrossRef
  17. Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells Ebrahimifar M, Roudsari MH , Kazemi SM , Shahmabadi HE , Kanaani L, Alavi SA , Vasfi MI . Asian Pacific Journal of Cancer Prevention : APJCP.2017;18(1). CrossRef
  18. Toxicity of Cisplatin-Loaded Poly Butyl Cyanoacrylate Nanoparticles in a Brain Cancer Cell Line: Anionic Polymerization Results Mohamadi N, Kazemi SM , Mohammadian M, Toofani Milani A, Moradi Y, Yasemi M, Ebrahimi far M, et al . Asian Pacific journal of cancer prevention: APJCP.2017;18(3). CrossRef
  19. Characteristics and Cytotoxic Effects of Nano-Liposomal Paclitaxel on Gastric Cancer Cells Abedi Cham Heidari Z, Ghanbarikondori P, Mortazavi Mamaghani E, Hheidari A, Saberian E, Mozaffari E, Alizadeh M, Allahyartorkaman M. Asian Pacific journal of cancer prevention: APJCP.2023;24(9). CrossRef
  20. Investigating the Properties and Cytotoxicity of Cisplatin-Loaded Nano-Polybutylcyanoacrylate on Breast Cancer Cells Gorgzadeh A, Hheidari A, Ghanbarikondori P, Arastonejad M, Goki TG , Aria M, Allahyartorkaman A, et al . Asian Pacific Journal of Cancer Biology.2023;8(4). CrossRef
  21. Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT) Tangsiri M, Hheidari A, Liaghat M, Razlansari M, Ebrahimi N, Akbari A, Varnosfaderani S, et al . Biomedicine & Pharmacotherapy.2023;170. CrossRef
  22. Toxicity of Carboplatin-Niosomal Nanoparticles in a Brain Cancer Cell Line Abbasi M, Reihanisaransari R, Poustchi F, Hheidari A, Ghanbarikondori P, Salehi H, Salehi V, Izadkhah M, Moazzam F, Allahyartorkaman M. Asian Pacific journal of cancer prevention: APJCP.2023;24(11). CrossRef
  23. Electromagnetically induced transparency for efficient optical modulation in a graphene-dielectric metasurface with surface roughness Kok Foong L, Shabani M, Sharghi A, Reihanisaransari R, Al-Bahrani M, Nguyen Le B, Khalilian A. Surfaces and Interfaces.2022;35. CrossRef
  24. Phytochemicals and cancer chemoprevention: epigenetic friends or foe? In: Rasooli I. Phytochemicals – Bioactivities and Impact on Health, InTech vel Szic KS , Palagani A, Hassannia B. Janeza Trdine 9, 51000 Rijeka, Croatia.2011.
  25. Strategies of functional food for cancer prevention in human beings Zeng Y, Yang J, Pu X, Du J, Yang T, Yang S, Zhu W. Asian Pacific journal of cancer prevention: APJCP.2013;14(3). CrossRef
  26. http://en.wikipedia. org/wiki/Cancer .
  27. Role of diet modification in cancer prevention Abdulla M, Gruber P. BioFactors (Oxford, England).2000;12(1-4). CrossRef
  28. Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting Lu B, Huang X, Mo J, Zhao W. Frontiers in Pharmacology.2016;7. CrossRef
  29. Mechanisms and insights into drug resistance in cancer Zahreddine H, Borden KLB . Frontiers in Pharmacology.2013;4. CrossRef
  30. Therapeutic nanoparticles for drug delivery in cancer Cho K, Wang X, Nie S, Chen Z, Shin DM . Clinical Cancer Research: An Official Journal of the American Association for Cancer Research.2008;14(5). CrossRef
  31. Nanoparticle and targeted systems for cancer therapy Brannon-Peppas L, Blanchette JO . Advanced Drug Delivery Reviews.2004;56(11). CrossRef
  32. Protein nanoparticle: A unique system as drug delivery vehicles Jahanshahi M, Babaei Z. AFRICAN JOURNAL OF BIOTECHNOLOGY.2008;7. CrossRef
  33. Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer Shenoy DB , Amiji MM . International Journal of Pharmaceutics.2005;293(1-2). CrossRef
  34. The impact of nanotechnology in drug delivery: global developments, Market Anal. Future Prospects (2005), Available from: (cited 31.03.09) Glen A. 2005.
  35. Safety of high-dose liposomal daunorubicin (daunoxome) for refractory or relapsed acute myeloblastic leukaemia Fassas A, Buffels R, Kaloyannidis P, Anagnostopoulos A. British Journal of Haematology.2003;122(1). CrossRef
  36. Factors affecting the clearance and biodistribution of polymeric nanoparticles Alexis F, Pridgen E, Molnar LK , Farokhzad OC . Molecular Pharmaceutics.2008;5(4). CrossRef
  37. Biodegradable polymeric nanoparticles based drug delivery systems Kumari A, Yadav SK , Yadav SC . Colloids and Surfaces. B, Biointerfaces.2010;75(1). CrossRef
  38. Drug Delivery of Cisplatin to Breast Cancer by Polybutylcyanoacrylate Nanoparticles Koohi M, Alavi SE , Shahbazian S, Ebrahimi H. Advances in Polymer Technology.2016;37. CrossRef
  39. Decomposition of cisplatin in aqueous solutions containing chlorides by ultrasonic energy and light Macka M, Borák J, Seménková L, Kiss F. Journal of Pharmaceutical Sciences.1994;83(6). CrossRef
  40. Efficacy of Cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma Ebrahimi Shahmabadi H, Movahedi F, Koohi Moftakhari Esfahani M, Alavi SE , Eslamifar A, Mohammadi Anaraki G, Akbarzadeh A. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine.2014;35(5). CrossRef
  41. Efficacy of Cisplatin-loaded poly butyl cyanoacrylate nanoparticles on the ovarian cancer: an in vitro study Bagherpour Doun SK , Alavi SE , Koohi Moftakhari Esfahani M, Ebrahimi Shahmabadi H, Alavi F, Hamzei S. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine.2014;35(8). CrossRef
  42. Polybutylcyanoacrylate nanoparticles and drugs of the platinum family: last status Fatemeh DRA , Ebrahimi Shahmabadi H, Abedi A, Alavi SE , Movahedi F, Koohi Moftakhari Esfahani M, Zadeh Mehrizi T, Akbarzadeh A. Indian journal of clinical biochemistry: IJCB.2014;29(3). CrossRef
  43. Evaluation of carrier capacity and release characteristics for poly( butyl 2-cyanoacrylate) nanoparticles Illum L, Khan M. A., Mak E., Davis S. S.. International Journal of Pharmaceutics.1986;30(1). CrossRef
  44. Mitoxantrone polybutyl cyanoacrylate NPs as an anti-neoplastic targeting drug delivery system. Int J Pharm 139, 1–8. Zhang Z, Liao G, Nagai T, Hou S. 1996.
  45. Core-shell type of nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] copolymers for drug delivery application: synthesis, characterization and in vitro degradation Huang C, Lee Y. International Journal of Pharmaceutics.2006;325(1-2). CrossRef
  46. Photonic Papers and Inks: Color Writing With Colorless Materials Fudouzi H, Xia Y. Advanced Materials.2003;15. CrossRef
  47. Amperometric determination of cholesterol in serum using a biosensor of cholesterol oxidase contained within a polypyrrole-hydrogel membrane | Request PDF Brahim S, Narinesingh D, Elie GA . ResearchGate.2001. CrossRef
  48. Adsorption of organic pollutants from effluents of a Kraft pulp mill on activated carbon and polymer resin Zhang Q, Chuang . ResearchGate.2001. CrossRef
  49. Colloidal drug delivery systems, vol. 66. New York: Marcel Dekker Kreuter J. NPs. In , Kreuter J, editor . 1994;:219-342.
  50. Controlled drug delivery with nanoparticles : current possibilities and future trends Couvreur P, Dubernet C, Puisieux F. European Journal of Pharmaceutics and Biopharmaceutics.1995.
  51. Poly(alkyl cyanoacrylate) NPs for delivery of anti-cancer drugs Murthy RSR , Reddy LH . Nanotechnol Cancer Therap.2006;15:252-280.
  52. Encapsulation of water-insoluble drugs in poly(butyl cyanoacrylate) nanoparticles Hekmatara T, Gelperina S, Vogel Vi, Yang S, Kreuter J. Journal of Nanoscience and Nanotechnology.2009;9(8). CrossRef
  53. Synthesis of high loading and encapsulation efficient paclitaxel-loaded poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion Huang C, Chen C, Lee Y. International Journal of Pharmaceutics.2007;338(1-2). CrossRef
  54. Synthesis of colloidal particles in miniemulsions Landfester K. Annual Review of Materials Research.2006;36. CrossRef
  55. Hydrogels in Miniemulsions Landfester K, Musyanovych A. Chemical Design of Responsive Microgels, 39-63 (2010).2011;234. CrossRef
  56. General Characteristics and Cytotoxic Effects of Nano-Poly (Butyl Cyanoacrylate) Containing Carboplatin on Ovarian Cancer Cells Kanaani L, Ebrahimi Far M, Kazemi SM , Choupani E, Mazloumi Tabrizi M, Ebrahimi Shahmabadi H, Akbarzadeh Khiyavi A. Asian Pacific journal of cancer prevention: APJCP.2017;18(1). CrossRef
  57. Polyreactions in Miniemulsions Antonietti M, Landfester K. Progress in Polymer Science.2002;27. CrossRef
  58. Synthesis of poly(alkyl cyanoacrylate)-based colloidal nanomedicines Nicolas J, Couvreur P. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology.2009;1(1). CrossRef
  59. Synthesis of poly(butylcyanoacrylate) nanocapsules by interfacial polymerization in miniemulsions for the delivery of DNA molecules Musyanovych A, Landfester K. Prog Colloid Polym Sci.2008;134:120-127.
  60. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Gelderblom H, Verweij J, Nooter K, Sparreboom A. European Journal of Cancer (Oxford, England: 1990).2001;37(13). CrossRef
  61. Taxol: a promising new drug of the '90s Rogers BB . Oncology Nursing Forum.1993;20(10).
  62. Reversion of multidrug resistance with polyalkylcyanoacrylate nanoparticles: towards a mechanism of action Verdière AC , Dubernet C, Némati F, Soma E, Appel M, Ferté J, Bernard S, Puisieux F, Couvreur P. British Journal of Cancer.1997;76(2). CrossRef
  63. Paclitaxel-loaded poly(n-butylcyanoacrylate) nanoparticle delivery system to overcome multidrug resistance in ovarian cancer Ren F, Chen R, Wang Y, Sun Y, Jiang Y, Li G. Pharmaceutical Research.2011;28(4). CrossRef
  64. Magnetically controlled targeted micro-carrier systems Gupta PK , Hung CT . Life Sciences.1989;44(3). CrossRef
  65. Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor Gao H, Wang J, Shen X, Deng Y, Zhang W. World Journal of Gastroenterology.2004;10(14). CrossRef
  66. Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis Li M, Tang Z, Zhang Y, Lv S, Li Q, Chen X. Acta Biomaterialia.2015;18. CrossRef
  67. Preliminary results of a phase II study of liposomal cisplatin-vinorelbine combination as first-line treatment in HER2/neu negative metastatic breast cancer (MBC) Farhat F, Ibrahim K, Kattan J, Bitar N, Jalloul R, Nsouly G, Ghosn M, et al . Journal of Clinical Oncology.2009;27. CrossRef
  68. Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles Cabeza L, Ortiz R, Arias JL , Prados J, Ruiz Martínez MA , Entrena JM , Luque R, Melguizo C. International Journal of Nanomedicine.2015;10. CrossRef
  69. Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles Snipstad S, Westrøm S, Mørch Y, Afadzi M, Åslund AK , Lange Davies C. Cancer Nanotechnology.2014;5(1). CrossRef
  70. Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system Friese A., Seiller E., Quack G., Lorenz B., Kreuter J.. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V.2000;49(2). CrossRef
  71. Nanoparticulate systems in drug delivery and targeting Kreuter J.. Journal of Drug Targeting.1995;3(3). CrossRef
  72. Nanoparticulate systems for brain delivery of drugs Kreuter J.. Advanced Drug Delivery Reviews.2001;47(1). CrossRef
  73. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity Olivier JC , Fenart L., Chauvet R., Pariat C., Cecchelli R., Couet W.. Pharmaceutical Research.1999;16(12). CrossRef
  74. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging Koffie RM , Farrar CT , Saidi L, William CM , Hyman BT , Spires-Jones TL . Proceedings of the National Academy of Sciences of the United States of America.2011;108(46). CrossRef
  75. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles Kreuter J, Ramge P, Petrov V, Hamm S, Gelperina SE , Engelhardt B, Alyautdin R, Briesen H, Begley DJ . Pharmaceutical Research.2003;20(3). CrossRef
  76. Surface engineered polymeric nanocarriers mediate the delivery of transferrin-methotrexate conjugates for an improved understanding of brain cancer Jain A, Jain A, Garg NK , Tyagi RK , Singh B, Katare OP , Webster TJ , Soni V. Acta Biomaterialia.2015;24. CrossRef
  77. Use of nanoparticles for cerebral cancer Kreuter J, Gelperina S. Tumori.2008;94(2). CrossRef
  78. Crucial ignored parameters on nanotoxicology: the importance of toxicity assay modifications and "cell vision" Laurent S, Burtea C, Thirifays C, Häfeli UO , Mahmoudi M. PloS One.2012;7(1). CrossRef
  79. Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles Mahmoudi M, Laurent S, Shokrgozar MA , Hosseinkhani M. ACS nano.2011;5(9). CrossRef
  80. Delivery of nanoparticles to the brain detected by fluorescence microscopy Reimold I, Domke D, Bender J, Seyfried CA , Radunz H, Fricker G. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V.2008;70(2). CrossRef
  81. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles Tian X, Lin X, Wei F, Feng W, Huang Z, Wang P, Ren L, Diao Y. International Journal of Nanomedicine.2011;6. CrossRef
  82. Improving Cancer Therapy: Design, Synthesis, and Evaluation of Carboplatin-Based Nanoliposomes against Breast Cancer Cell Lines Hadisadegh SN , Ghanbarikondori P, Sedighi A, Afyouni I, Javadpour N, Ebadi M. Asian Pacific Journal of Cancer Biology.2024;9(2). CrossRef
  83. Oral Cancer and HPV: Review Article Pirmoradi Z, Nazari K, Shafiee N, Nikoukar N, Minoo S, Ghasemi H, Ghanbarikondori P, Allahyartorkaman M. Asian Pacific Journal of Cancer Biology.2024;9(1). CrossRef
  84. Energy cycle assessment of bioethanol production from sugarcane bagasse by life cycle approach using the fermentation conversion process Satari Dibazar A, Aliasghar A, Behzadnezhad A, Shakiba A, Pazoki M. Biomass Conversion and Biorefinery.2023. CrossRef
  85. Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis Basmenj ER , Arastonejad M, Mamizadeh M, Alem M, KhalatbariLimaki M, Ghiabi S, Khamesipour A, Majidiani H, Shams M, Irannejad H. Scientific Reports.2023;13(1). CrossRef
  86. Additive Manufacturing of Composite Polymers: Thermomechanical FEA and Experimental Study Behseresht S, Park YH . Materials (Basel, Switzerland).2024;17(8). CrossRef
  87. In Silico Analysis of Stem Cells Mechanical Stimulations for Mechnoregulation Toward Cardiomyocytes Ebad M, Vahidi B. International Journal of Engineering.2022;35. CrossRef
  88. Mobility and bioaccessibility of arsenic (As) bound to titanium dioxide (TiO2) water treatment residuals (WTRs) Zimmerman AJ , Garcia Gutierrez D, Shaghaghi N, Sharma A, Deonarine A, Landrot G, Weindorf DC , Siebecker MG . Environmental Pollution (Barking, Essex: 1987).2023;326. CrossRef
  89. Pahnehkolaei SMH, Kachabi A, Sipey MH,Ganji DD. New approach method for solving nonlinear differential equations of blood flow with nanoparticle in presence of magnetic field. arXiv preprint arXiv:2402.16208 2024. CrossRef
  90. Wavelength Effect in Laser Therapy of Diabetic Rats on Oxidants: AGEs, AOPP, ox-LDL Levels Mirmiranpour H, Amjadi A, Khandani S, Shafaee Y, Sobhani S. International Journal of Clinical and Experimental Medical Sciences.2020;6. CrossRef
  91. Modeling of Mechanical Behaviors and Interphase Properties of Polymer/Nanodiamond Composites for Biomedical Products Jamali S, Zare Y, Rhee KY . Journal of Materials Research and Technology.2022;19. CrossRef
  92. Study of solute-solvent interactions using volumetric properties for the ternary {L-Serine +H2O+NaBr, KBr, LiBr} solutions at different temperatures and ambient pressure Ghasemi H, Rafiee H. Chemical Data Collections.2020;29. CrossRef
  93. Plasmonic Heating of Gold Nanoparticles for Controlling of Current Across Lipid Membranes in Modulating Neuronal Behavior Applications. 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC), Munich, Germany, 2019, pp. 1-1 seyed Nazari MH , Ghorbani A, Akbari F, Babaei JF , Eliassi A, Dragahi L, Latifi H, Zibaii MI . 2019. CrossRef
  94. Switchable Ultra-Wideband All-Optical Quantum Dot Reflective Semiconductor Optical Amplifier Nahaei FS , Rostami A, Mirtagioglu H, Maghoul A, Simonsen I. Nanomaterials (Basel, Switzerland).2023;13(4). CrossRef
  95. A rare case of cutaneous mucormycosis in the forearm: A case report Shadidi-Asil R, Kialashaki M, Fateh A, Ramezani A, Zamani A, Ebrahimian M. International Journal of Surgery Case Reports.2022;94. CrossRef
  96. Evaluation of the difficulty of laparoscopic cholecystectomy during COVID-19 pandemic using externally validated prediction models: A retrospective cohort study Hatampour Geraviani K, Ebrahimian M, Zamani A, Zardoui A, Ramezani A, Ghahremanloo K, Mirhashemi S, Soori M, Rashno F, Shadidi Asil R, Hajinasrollah E. International Journal of Surgery Open.2023;61. CrossRef
  97. Prevalence of cataract and its contributing factors in Iranian elderly population: the Gilan eye study Ramezani A, Sabbaghi H, Katibeh M, Ahmadieh H, Kheiri B, Yaseri M, Moradian S, et al . International Ophthalmology.2023;43(12). CrossRef
  98. Apple's Knowledge Navigator: Why Doesn't that Conversational Agent Exist Yet? ACM ISBN 979-8-4007-0330-0/24/05 Amanda K. Newendorp , Mohammadamin Sanaei , AJ Perron , H Sabouni , et al . . CrossRef
  99. Investigating the Effect of Appropriate Personal Protective Equipment on the Stress Level of Care Workers in the Covid19 Epidemic Sadeghipor N, Aghdam BH . Health Science Journal.0;0(0). CrossRef
  100. Evaluation of Burnout and Job Stress in Care Worker and Comparison between Front-Line and Second-Line in Care Worker during Coronavirus Epidemic Sadeghipour N, Aghdam B, Kabiri S. Health Science Journal.0;0(0). CrossRef
  101. Assessment and Comparative Study of Job Stress in Jam Hospital jobs, Tehran City Sadeghpour E, Sangchini EK . Health Science Journal.2020;14(8). CrossRef
  102. Investigating the pesticides impact on mental health of exposed workers – Iran. MAR Case Reports 2.6 Niki Sadeghipour , Sahra Kairi , Dr Babak Heidari Aghdam . 2021. CrossRef
  103. Knowledge and Attitude of Cancer Patients’ Companions towards Chemotherapy and Radiotherapy-induced Oral Complications and Dental Considerations Maryam Jalili Sadrabad , Farahnaz Ghahremanfard , Shabnam Sohanian , Maede Mobarhan , Anahid Nabavi , Elham Saberian . Iranian Red Crescent Medical Journal.2023 Feb 27. CrossRef
  104. Gingival bullae-A rare visible case report. Journal of Research in Applied and Basic Medical Sciences Jalili Sadrabad M, Saberian E, Saberian E, Behrad S. .2024 Jan 10 [cited 2024 May 6].;10(1):31–4. Available from:
  105. Dental Pulp Stem Cells in Pulp Regeneration Saberian E, Jalili Sadrabad M, Petrášová A, A I. SunText Review of Medical & Clinical Research.2021;02. CrossRef
  106. Success in Tooth Bud Regeneration: A Short Communication Sadrabad MJ , Saberian E, Izadi A, Emami R, Ghadyani F. Journal of Endodontics.2024;50(3). CrossRef
  107. “Optimization of Sequential Microwave-Ultrasound-Assisted Extraction for Maximum Recovery of Quercetin and Total Flavonoids from Red Onion (Allium cepa L.) Skin Wastes,” arXiv preprint arXiv:2104.06109, 2021 Z. J. Velisdeh , G. D. Najafpour , M. Mohammadi , F. Poureini . .
  108. Lutein with various therapeutic activities based on micro and nanoformulations: A systematic mini-review Maghsoudloo M, Bagheri Shahzadeh Aliakbari R. Micro Nano Bio Aspects.2023;2(4). CrossRef
  109. Anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects of bisdemethoxycurcumin: Micro and nano facets Aminnezhad S, Maghsoudloo M, Bagheri Shahzadeh Aliakbari R. Micro Nano Bio Aspects.2023;2(4). CrossRef
  110. "Pharmaceutical, nutritional, and cosmetic potentials of saponins and their derivatives." Nano Micro Biosystems Maghsoudloo, Maral, , Razieh Bagheri Shahzadeh Aliakbari, , Zeinab Jabbari Velisdeh. . 2023;2(4):1-6. CrossRef
  111. Study of Marital Satisfaction in Autistic Families Montazeri Ghahjavarestani A, Martín B, Sanahuja J. Autism and Developmental Disorders.2020;18. CrossRef
  112. Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair Shineh G, Mobaraki M, Afzali E, Alakija F, Velisdeh Z, Mills D. Biomedical Materials & Devices.2024. CrossRef


© Asian Pacific Journal of Cancer Biology , 2024

Author Details

Vahid Salehi
Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.

Mohaddeseh Izadkhah
Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.

Hanifeh Salehi
Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.

Niki Sadeghi Pour
Jam General Hospital Tehran, Iran.

Parizad Ghanbarikondori
Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.

How to Cite

Salehi V, Izadkhah M, Salehi H, Sadeghi Pour N, Ghanbarikondori P. The Application of Polybutyl Cyanoacrylate (PBCA) Nanoparticles in Delivering Cancer Drugs. apjcb [Internet]. 26May2024 [cited 21Jun.2024];9(2):209-18. Available from:
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