The IRX3 Gene; the Missing Link between the FTO Gene and Obesity

Authors

  • Saeid Doaei Students `Research Committee, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Maryam Gholamalizadeh
  • Alireza Mousavi Jarrahi Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Marjan Badakhanian Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. 5Urmia University of Medical Sciences, Urmia, Iran.
  • Rahim Najafi Urmia University of Medical Sciences, Urmia, Iran.

Keywords:

IRX3 gene, the FTO gene, Obesity

Abstract

Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity.
Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied.
Results: Only a Few studies have examined the association between the IRX3 gene with the FTO gene and obesity. However, all of them reported that the FTO gene can influence the IRX3 gene expression. Also, it’s reported that the IRX3 gene expression level has a significant association with body weight and body composition.
Conclusions: The FTO gene effects on obesity is in part due to its impact on the IRX3 gene expression level. The further studies are needed to investigate this interaction and clarify the existing mechanisms.

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Published

2016-06-25

Issue

Vol. 1 No. 2 (2016)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).