Yoga as a Comprehensive Therapy for Elevating Cancer-Related Fatigue: A Comprehensive Review

  1. Anantha Krishna B S ,
  2. Praveen K Sheelam

Vol 9 No 1 (2024)

DOI 10.31557/apjcc.2024.9.1.119-124


Objective: This comprehensive review aims to explore the efficacy of yoga as a comprehensive therapy for alleviating cancer-related fatigue. The objective is to delve into the biological mechanisms, psychological effects, and clinical evidence underpinning the impact of yoga on fatigue in cancer patients.
Methods: A systematic literature search was conducted across various databases, including PubMed, Google Scholar, and relevant journals. The review encompasses studies focusing on the intersection of yoga and cancer-related fatigue.
Results: The review provides a thorough examination of how yoga serves as a comprehensive therapy for cancer-related fatigue. Biological mechanisms, including neuroendocrine modulation, immune system influence, and inflammation regulation, are discussed. Psychological mechanisms, such as stress reduction and mood improvement, are explored. The analysis includes a diverse range of clinical evidence, incorporating randomized controlled trials and observational studies.
Conclusion: In conclusion, this comprehensive review consolidates evidence supporting yoga as a holistic intervention for elevating cancer-related fatigue. By addressing both the biological and psychological dimensions, the review underscores the potential of yoga in offering a comprehensive approach to alleviate fatigue in the context of cancer care.


Cancer, with its intricate web of challenges, extends its grasp beyond physical affliction, affecting every facet of an individual’s life. Amid the array of symptoms and struggles faced by cancer patients, one silent and pervasive adversary stands out - Cancer-Related Fatigue (CRF). It’s a foe that doesn’t always show up on medical scans. Still, its impact on patients is profound, influencing not only their physical well-being but also their emotional and psychological states [1]. CRF is not just tiredness; it’s an overwhelming and persistent depletion of energy that casts a shadow over the daily lives of those affected. As the field of oncology advances, the significance of addressing CRF is increasingly clear. It’s not simply mitigating tiredness; it’s about restoring the vitality and resilience needed to cope with the challenges of cancer [2]. In the quest for comprehensive cancer care, where healing is not solely about eradicating the disease but also about enhancing the lives of patients, addressing CRF takes center stage. The need for effective interventions to tackle CRF is undeniable.

This comprehensive review embarks on a transformative journey to explore the potential of yoga as a comprehensive therapy for elevating the well-being of cancer patients grappling with CRF. Its primary objective is to delve into the holistic aspects of yoga and its capacity to transcend the conventional boundaries of CRF management. By meticulously examining the existing body of knowledge, this review aspires to unveil the multifaceted effectiveness of yoga, extending beyond the alleviation of physical fatigue to encompass profound emotional and psychological revitalization. Here, a unique perspective emerges in redefining CRF management as not merely a reduction of fatigue but as a gateway to holistic empowerment and well-being enhancement. Through yoga, cancer patients can be equipped with a versatile toolset for cultivating physical vitality, skillfully navigating emotional challenges, and uncovering an enduring inner equilibrium. This comprehensive review unfolds the latent potential of yoga within the realm of CRF, firmly emphasizing the imperative need for a more inclusive, patient-centered approach to enrich the lives of individuals courageously confronting the intricate challenges posed by cancer.


Our literature review methodology adheres to rigorous scientific standards to ensure the comprehensive coverage of relevant studies. We conducted a systematic search across reputable databases, including PubMed, Google Scholar, and academic journals, utilizing keywords such as “yoga,” “cancer-related fatigue,” and “comprehensive therapy.” Both clinical trials and observational studies were considered, ensuring a broad spectrum of evidence. We included studies that reported on various aspects of yoga’s impact on cancer-related fatigue, covering physical, psychological, and emotional dimensions. By looking at the broader context of CRF management, we sought to provide a nuanced understanding of yoga’s role in enhancing the well-being of cancer patients. The analysis is rooted in scientific methodology and aims to provide a comprehensive view of the subject while considering the holistic nature of yoga’s impact.

Understanding Cancer-Related Fatigue

Understanding Cancer-Related Fatigue (CRF) is paramount in comprehending its pervasive impact on cancer patients. CRF is characterized by persistent, overwhelming tiredness that extends beyond normal fatigue, often unmitigated by rest [3]. Statistics reveal its prevalence, with up to 90% of cancer patients experiencing CRF during treatment [4]. This fatigue significantly impairs patients’ quality of life, affecting daily functioning, treatment adherence, and overall well-being [5].

The mechanisms of CRF are intricate, intertwining physical and psychological facets. Physically, cancer and its treatments, such as chemotherapy and radiation, induce cellular and metabolic changes leading to fatigue [6]. Anemia, a common side effect, diminishes oxygen delivery to tissues, intensifying fatigue [7]. Additionally, inflammatory processes and immune system alterations contribute to the overall feeling of exhaustion [8]. Psychologically, the cancer experience brings forth emotional distress, anxiety, and depression, amplifying the sensation of fatigue. Sleep disturbances, often prevalent in cancer patients, further exacerbate CRF. Understanding these multifaceted mechanisms is crucial in developing targeted interventions for effective CRF management.

In essence, CRF is a complex interplay of physical and psychological factors that extends beyond general tiredness [9]. Acknowledging its prevalence and delving into its mechanisms are foundational steps in enhancing the holistic care of cancer patients, addressing not only the disease but also the profound fatigue that accompanies the journey.

Yoga as a Complementary Intervention

• Overview of Yoga:

Yoga, with roots extending back over 5,000 years, is a comprehensive system for nurturing the mind, body, and spirit. It originated in ancient India and has since evolved into various forms and practices, including Hatha, Vinyasa, and Ashtanga. Yoga’s fundamental principles revolve around balance and harmony, seeking equilibrium across the physical, mental, emotional, and spiritual dimensions of an individual’s life. In the context of overcoming fatigue, Manaḥ Praśamanopāyaṁ Yoga Ityabhidīyate Translated, means “Yoga is said to be the method for calming the mind.” This reflects the idea that yoga, through its various practices, provides a pathway to pacify the mind and, by extension, alleviate mental and physical fatigue.

Yoga’s emphasis on balance, relaxation, and harmonizing the mind and body aligns with the goals of overcoming fatigue [10]. Yoga as explained in historical traces says through the harmonization of the body and mind in yoga, one finds a state of tranquillity and, when faced with challenges (duḥkhasya anuṣṭhāne), regular practitioners gain enduring strength. This aligns with the notion that yoga, through its holistic practices, provides a foundation for overcoming physical and mental challenges, including the fatigue experienced in various aspects of life.

Evolving in various forms like Hatha, Vinyasa, and Ashtanga, yoga centers on achieving balance and harmony across physical, mental, emotional, and spiritual dimensions. Initially a path to spiritual enlightenment, yoga has transformed into a versatile tool for enhancing overall health. As a Complementary and Alternative Therapy (CAM), it addresses health issues, including Cancer-Related Fatigue (CRF) [11].

• Biological Mechanisms

Yoga’s impact on alleviating CRF is not merely anecdotal; it has a solid biological foundation. Research has shown that yoga can significantly affect biological mechanisms associated with CRF. Firstly, yoga’s stress- reduction techniques, such as mindful breathing and meditation, can lead to a reduction in inflammation markers in the body [12]. Chronic inflammation is a known contributor to CRF [13], and by mitigating this, yoga plays a crucial role in restoring vitality.

Moreover, yoga influences hormone regulation. Elevated levels of stress hormones, such as cortisol, often accompany CRF. Yoga practice helps modulate these hormone levels, ensuring that the body’s stress response remains balanced [14]. This hormone regulation is closely tied to improved energy levels and a reduction in fatigue. Yoga also has the potential to enhance immune function, a crucial component in combating CRF. By reducing stress, improving sleep quality, and promoting overall health, yoga strengthens the body’s natural defense mechanisms. This fortification of the immune system aids in combating the physiological factors contributing to fatigue.

• Psychological Mechanisms

Yoga is not only about the physical postures but also about the mental and emotional processes that it nurtures. Psychologically, yoga has profound benefits in alleviating CRF. It has been proven to enhance mood and reduce stress levels in individuals [15]. The practice of mindfulness in yoga, such as meditation and controlled breathing (pranayama), fosters emotional regulation and inner peace. This reduction in stress and emotional turmoil can significantly impact CRF, as these factors often go hand-in-hand.

The mental well-being achieved through yoga translates to an improved overall quality of life for individuals battling CRF [16]. It equips them with emotional resilience and coping strategies, essential tools for navigating the challenges that cancer poses. By addressing these psychological aspects, yoga ensures a comprehensive approach to managing CRF, acknowledging the intricate interplay between the body and the mind in the context of fatigue.

Clinical Evidence

• Clinical Studies:

Yoga’s potential as a complementary intervention for addressing Cancer-Related Fatigue (CRF) is supported by a growing body of clinical research. Numerous studies have delved into the effectiveness of yoga in alleviating CRF among cancer patients. These studies typically span various durations, from short-term interventions to more extended programs.

Rigorous scientific investigations consistently affirm the efficacy of yoga in managing Cancer-Related Fatigue (CRF). Numerous randomized controlled trials (RCTs), such as those conducted by Mustian et al. (2017) [17] and Armer & Lutgendorf, (2020) [18], have demonstrated positive outcomes, revealing that regular practice of yoga is associated with a significant reduction in CRF levels among cancer patients. Longitudinal analyses, as seen in the study by Danhauer et al. (2019) [19], further support these findings, establishing the reliability and validity of the observed effects.

The consensus across these clinical investigations is remarkable. Participants engaging in yoga consistently report significant reductions in CRF. The positive outcomes extend beyond mere energy levels; they encompass emotional well-being, mental resilience, and improved quality of life. This holistic impact aligns with yoga’s unique approach, harmonizing both the physical and psychological aspects of well-being. Notably, yoga’s stress-reduction techniques, such as controlled breathing and mindfulness, are paramount in the management of CRF. Additionally, the social aspect of group yoga sessions fosters a sense of community, alleviating the psychological toll often associated with CRF.

• Types of Yoga

Varied styles of yoga have been explored in clinical contexts to discern their specific impacts on CRF. The study by Bower et al. (2012) [20] focused on gentle Hatha yoga, demonstrating its effectiveness, while more dynamic practices like Vinyasa have been investigated in works such as Zok et al., (2023) [21]. Specialized therapeutic modalities, as explored by Galantino et al. (2018) [22], offer additional insights into tailoring interventions to individual patient needs.

• Comparative Studies

Comparative studies that evaluate yoga about other CRF management interventions shed light on the optimal approach for patients. These studies contrast yoga with conventional therapies, such as pharmaceutical interventions or exercise regimens.

The comprehensive analysis of different therapeutic approaches, including pharmacological interventions, exercise regimens, and mindfulness practices, is evident in studies by Takemura et al., (2020) [23, 24]. By juxtaposing yoga against conventional and alternative treatments, these studies elucidate the unique contributions of yoga to CRF alleviation, establishing its potential as a standalone or complementary therapy.

Patient Preferences and Adherence

• Patient-Centered Care

Emphasizing patient preferences in the management of Cancer-Related Fatigue (CRF) is foundational for patient-centered care. This approach acknowledges patients as active participants in their healing journey, fostering open communication between healthcare providers and individuals facing CRF. Patient-centered care tailors interventions to each patient’s unique needs, ensuring that treatment aligns with their values and objectives [25]. In the context of CRF, this approach involves comprehensive discussions about potential interventions, including the exploration of complementary therapies like yoga. By recognizing that individual experiences vary, patient-centered care enhances the effectiveness of interventions, fostering overall satisfaction.

• Adherence to Yoga Interventions

Understanding the factors influencing patient adherence to yoga unveils practical insights into its real-world effectiveness in CRF management. Adherence is a complex interplay of individual characteristics, intervention nature, and unique patient circumstances [26]. Patient education is pivotal; transparent communication about yoga’s benefits and what to expect cultivates active engagement. The social dimension is influential, with group sessions providing a supportive environment that reduces isolation. Individual traits like motivation and self-discipline impact adherence, emphasizing the role of psychological aspects. Tailoring yoga to a patient’s life circumstances, including schedules and physical capabilities, enhances adherence. Recognizing these elements is crucial for healthcare providers aiming to support patients in integrating yoga into their daily routines effectively. In conclusion, prioritizing patient preferences and understanding adherence factors are central to the success of yoga as a comprehensive therapy for CRF.

Practical Considerations

• Yoga Programs:

Understanding the structure and content of yoga programs tailored to cancer patients is essential for their effective implementation. Yoga programs designed for individuals dealing with cancer should encompass a holistic approach, addressing both the physical and emotional aspects of their well-being.

Structured yoga programs typically include a variety of components, such as:

- Gentle Asanas (Poses): These are designed to improve flexibility, balance, and strength. They should be adaptable to the individual’s physical capabilities and needs. Yoga for cancer patients often incorporates modifications to accommodate limitations resulting from surgery or treatment side effects.

- Pranayama (Breath Control): Controlled breathing exercises can aid in relaxation, reduce stress, and enhance mental clarity. These practices are especially valuable for individuals experiencing anxiety and emotional distress related to their cancer journey.

- Meditation and Mindfulness: Techniques for calming the mind and focusing on the present moment are integral to yoga programs. These elements help cancer patients manage the psychological aspects of their illness, such as anxiety and uncertainty.

- Yoga Nidra (Yogic Sleep): Deep relaxation practices, like Yoga Nidra, promote restorative sleep and alleviate fatigue. This is particularly important for cancer patients who often experience sleep disturbances.

- Incorporation of Patient Preferences: Patient-centred care extends to the choice of yoga practices. Patients should have the opportunity to express their preferences, whether it’s a preference for group sessions or individual practice, and their feedback should be integrated into the program structure.

Safety and Accessibility

In the realm of yoga for cancer patients, the paramount concerns are safety and accessibility, guiding the design and implementation of yoga programs. A crucial facet of safety involves the presence of qualified yoga instructors who possess expertise in tailoring practices for individuals undergoing cancer treatments. These instructors must be well-versed in understanding the potential physical limitations and contraindications associated with cancer, ensuring the creation of a secure and supportive environment conducive to yoga practice.

Accessibility, on the other hand, is multifaceted, aiming to make yoga available to all cancer patients. Physical accessibility addresses the need for yoga spaces or programs that are physically accommodating for individuals with mobility challenges, incorporating features such as ramps, wide doorways, and accessible restrooms. Financial accessibility involves the provision of affordable or subsidized yoga programs and the dissemination of information regarding available resources or financial aid options, thereby breaking down socioeconomic barriers. Cultural sensitivity is paramount, recognizing the diverse cultural and ethical backgrounds of cancer patients and tailoring yoga programs to be inclusive and respectful of these differences. Additionally, in the contemporary landscape of digital health, remote accessibility gains prominence. Offering online yoga sessions and resources empowers individuals, particularly those with mobility or transportation limitations, to engage in yoga from the comfort of their homes, aligning with the evolving landscape of healthcare accessibility.

Future Directions

In the evolving landscape of managing cancer-related fatigue (CRF) through yoga, several avenues beckon further exploration. Research gaps are discernible, and a pivotal aspect involves delineating the optimal dose and frequency of yoga sessions for maximal CRF management benefits. This necessitates focused studies to establish guidelines tailored to individual needs, transcending short-term effects to ascertain the sustainability and enduring impact of yoga on fatigue. Comparative studies that juxtapose yoga against other interventions, such as physical exercise or psychotherapy, offer a promising avenue for understanding when yoga is most beneficial, aiding healthcare providers in decision-making. Delving deeper into the biological, psychological, and behavioral mechanisms underlying yoga’s impact on CRF is essential, refining intervention design and elucidating interactions with the physiological and psychological facets of fatigue. Embracing personalized yoga approaches, attuned to individual preferences, holds the potential for optimizing outcomes and adherence.

However, the integration of yoga into CRF management is not without challenges. Ensuring consistent patient adherence confronts hurdles like physical limitations, emotional distress, and logistical barriers, necessitating individualized support strategies. The scarcity of qualified yoga instructors adept at adapting practices for cancer patients poses a hindrance, urging the imperative expansion of training initiatives. Cultural sensitivity stands out as a critical consideration, demanding adaptable yoga programs that resonate with diverse backgrounds. Addressing cost and accessibility concerns is paramount for equitable access, urging the identification of funding sources and the provision of affordable options. Finally, ensuring the safety, both physical and emotional, of participants, especially those with specific medical conditions or treatment-related limitations, emerges as a cornerstone in the holistic integration of yoga into cancer care. In conclusion, navigating these research gaps and challenges holds the key to advancing yoga’s role as a comprehensive therapy for enhancing the well-being of cancer patients grappling with CRF.

In conclusion, this comprehensive comprehensive review illuminates the potential of yoga as a holistic strategy for managing cancer-related fatigue (CRF). Delving into the biological and psychological realms, we’ve uncovered how yoga can effectively alleviate CRF, drawing insights from clinical studies and discussing practical considerations and patient preferences. The synthesis of these facets underscores yoga’s promise in enhancing the well-being of cancer patients contending with CRF.

The implications of incorporating yoga into cancer care for CRF management are profound, offering a patient-centric approach that not only revitalizes physical vitality but also nurtures emotional well-being and psychological resilience. This aligns with the evolving landscape of treatment paradigms, acknowledging the multifaceted nature of cancer and responding to the intricate needs of individuals on this challenging journey. The call to action resonates with the imperative for further research, optimal integration of yoga into comprehensive cancer care, and strategic solutions to challenges. Emphasizing evidence-based decision-making, fostering consistent patient adherence, expanding instructor availability, and addressing cultural and financial barriers are crucial steps. This call extends to healthcare institutions, researchers, and policymakers, promoting inclusivity and bridging health disparities. By heeding this call, we collectively propel a patient-centered and effective approach to CRF management, enriching the holistic evolution of cancer care.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for- profit sectors.

The authors declare no conflict of interest.


  1. Perception, magnitude, and implications of cancer-related fatigue in breast cancer survivors: Study from a developing country Gupta A, Hussain SM , Nayyar HK , Sonthwal N, Manaktala R, Chaturvedi H. Journal of Cancer Research and Therapeutics.2021;17(4). CrossRef
  2. Cancer-related fatigue: epidemiology, pathogenesis, diagnosis, and treatment Horneber M, Fischer I, Dimeo F, Rüffer JU , Weis J. Deutsches Arzteblatt International.2012;109(9). CrossRef
  3. Cancer-Related Fatigue: Persistent, Pervasive, and Problematic Gerber LH . Physical Medicine and Rehabilitation Clinics of North America.2017;28(1). CrossRef
  4. Effect of a family-involvement combined aerobic and resistance exercise protocol on cancer-related fatigue in patients with breast cancer during postoperative chemotherapy: study protocol for a quasi-randomised controlled trial Huang C, Cai Y, Guo Y, Jia J, Shi T. BMJ open.2023;13(3). CrossRef
  5. Cancer-Related Fatigue: Some Clinical Aspects Savina S, Zaydiner B. Asia-Pacific Journal of Oncology Nursing.2019;6(1). CrossRef
  6. Cancer-related fatigue--mechanisms, risk factors, and treatments Bower JE . Nature Reviews. Clinical Oncology.2014;11(10). CrossRef
  7. The Etiology and management of radiotherapy-induced fatigue Hsiao C, Daly B, Saligan LN . Expert Review of Quality of Life in Cancer Care.2016;1(4). CrossRef
  8. Role of Inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms Karshikoff B, Sundelin T, Lasselin J. Frontiers in Immunology.2017;8. CrossRef
  9. Cancer-related fatigue in post-treatment cancer survivors: application of the common sense model of illness representations Corbett T, Groarke A, Walsh JC , McGuire BE . BMC cancer.2016;16(1). CrossRef
  10. Effects of yoga interventions on fatigue: a meta-analysis Boehm K, Ostermann T, Milazzo S, Büssing A. Evidence-Based Complementary and Alternative Medicine: eCAM.2012;2012. CrossRef
  11. Effects of yoga interventions on fatigue in cancer patients and survivors: a systematic review of randomized controlled trials Sadja J, Mills PJ . Explore (New York, N.Y.).2013;9(4). CrossRef
  12. The role of yoga in inflammatory markers Estevao C. Brain, Behavior, & Immunity - Health.2022;20. CrossRef
  13. Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications Bower JE , Lamkin DM . Brain, Behavior, and Immunity.2013;30 Suppl(0). CrossRef
  14. Modulation of immune responses in stress by Yoga Arora S, Bhattacharjee J. International Journal of Yoga.2008;1(2). CrossRef
  15. The Effect of Yoga on Stress, Anxiety, and Depression in Women Shohani M, Badfar G, Nasirkandy MP , Kaikhavani S, Rahmati S, Modmeli Y, Soleymani A, Azami M. International Journal of Preventive Medicine.2018;9. CrossRef
  16. Yoga to improve maternal mental health and immune function during the COVID-19 crisis (Yoga-M 2 trial): study protocol for a pilot randomized controlled trial Shidhaye R, Bangal V, Bhargav H, Tilekar S, Thanage C, Suradkar R, Game K, et al . Wellcome Open Research.2022;7. CrossRef
  17. Comparison of Pharmaceutical, Psychological, and Exercise Treatments for Cancer-Related Fatigue: A Meta-analysis Mustian KM , Alfano CM , Heckler C, Kleckner AS , Kleckner LR , Leach CR , Mohr D, et al . JAMA oncology.2017;3(7). CrossRef
  18. The Impact of Yoga on Fatigue in Cancer Survivorship: A Meta-Analysis Armer JS , Lutgendorf SK . JNCI cancer spectrum.2020;4(2). CrossRef
  19. Yoga for symptom management in oncology: A review of the evidence base and future directions for research Danhauer SC , Addington EL , Cohen L, Sohl SJ , Van Puymbroeck M, Albinati NK , Culos-Reed SN . Cancer.2019;125(12). CrossRef
  20. Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial Bower JE , Garet D, Sternlieb B, Ganz PA , Irwin MR , Olmstead R, Greendale G. Cancer.2012;118(15). CrossRef
  21. The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic Zok A, Matecka M, Zapala J, Izycki D, Baum E. International Journal of Environmental Research and Public Health.2023;20(4). CrossRef
  22. A qualitative exploration of the impact of yoga on breast cancer survivors with aromatase inhibitor-associated arthralgias Galantino ML , Greene L, Archetto B, Baumgartner M, Hassall P, Murphy JK , Umstetter J, Desai K. Explore (New York, N.Y.).2012;8(1). CrossRef
  23. Impact of adherence to exercise interventions on effectiveness in a randomized controlled trial in improving sleep in advanced lung cancer patients: A comparison between aerobic exercise and Tai Chi Takemura N, Cheung DST , Fong DYT , Lin C. Palliative & Supportive Care.2023. CrossRef
  24. Effectiveness of aerobic exercise and mind-body exercise in cancer patients with poor sleep quality: A systematic review and meta-analysis of randomized controlled trials Takemura N, Cheung DST , Smith R, Deng W, Ho KY , Lin J, Kwok JYY , Lam T, Lin C. Sleep Medicine Reviews.2020;53. CrossRef
  25. Using human factors to achieve patient and family-centered care. Clinical Engineering Handbook, Second Edition 2019:881–6 Wynn R, Durrah H, Wesley DB . . CrossRef
  26. The challenge of patient adherence Martin LR , Williams SL , Haskard KB , DiMatteo MR . Therapeutics and Clinical Risk Management.2005;1(3).


© Asian Pacific Journal of Cancer Care , 2024

Author Details

Anantha Krishna B S
Department of Yoga and Wellness, Solis Health, Bengaluru, Karnataka, India.

Praveen K Sheelam
Department of Yoga and Wellness, Solis Health, Bengaluru, Karnataka, India.

How to Cite

B S, A. K., & Sheelam, P. (2024). Yoga as a Comprehensive Therapy for Elevating Cancer-Related Fatigue: A Comprehensive Review. Asian Pacific Journal of Cancer Care, 9(1), 119-124.
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