Small Cell Neuroendocrine Carcinoma of the Cervix with Past  History of Uterine Fibroids: A Rare Case Report

Javeria Haider; Humera Mahmood; Muhammad Faheem; Abdullah .; Wania Sultan

doi:10.31557/apjcc.2025.10.1.377-380

Authors

Javeria Haider Department of Oncology Atomic Energy Cancer hospital NORI, Islamabad, Pakistan.
Humera Mahmood Department of Oncology Atomic Energy Cancer hospital NORI, Islamabad, Pakistan.
Muhammad Faheem Department of Oncology Atomic Energy Cancer hospital NORI, Islamabad, Pakistan.
Abdullah . Rawalpindi Medical University, Pakistan.
Wania Sultan Dow Medical University Karachi, Pakistan.

DOI:

https://doi.org/10.31557/apjcc.2025.10.1.377-380

Keywords:

Small cell neuroendocrine carcinoma of the cervix; cervical carcinoma; neuroendocrine tumors

Abstract

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is an aggressive uterine tumor, comprising less than 2% of all cases of invasive cervical cancer. This malignancy is frequently associated with high-risk human papillomavirus (HPV) type 18. Compared to squamous cell carcinoma or adenocarcinoma, SCNECC is characterized by a significantly higher risk of both nodal and distant metastases. The scarcity of clinical trials and evidence-based treatment protocols results in a reliance on case series and individual case reports for guidance. This case report delineates a successful management strategy for SCNECC utilizing a regimen of chemotherapy in conjunction with concomitant chemoradiation therapy (CCRT) and single-channel brachytherapy.