Diffuse Large B-Cell Lymphoma Beyond the Nodes: A Case  Series of Rare Extranodal Presentations in the Nasopharynx,  Breast and Central Nervous System

Neha Yadav; Shabana Andleeb Ansari; Tejaswi Gupta; Ganesh Bhat; Priyanka Mishra; Shiv Prasad Yadav

doi:10.31557/apjcc.2026.11.2.303-310

Authors

Neha Yadav Assistant Professor, Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Shabana Andleeb Ansari Associate Professor, Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Tejaswi Gupta Assistant Professor Associate Professor, Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Ganesh Bhat Assistant Professor, Department of Endocrine Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Priyanka Mishra Junior Resident, Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Shiv Prasad Yadav Consultant radiologist, Department of Radiodiagnosis, Apollomedics Superspeciality Hospital Lucknow, Uttar Pradesh, India.

DOI:

https://doi.org/10.31557/apjcc.2026.11.2.303-310

Keywords:

BCL6, MUM1, CD10

Abstract

Background: Lymphomas may originate from nodal or extranodal sites, with an increasing proportion of patients presenting with extranodal non-Hodgkin Lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL, seldom involves the nasopharynx, breast or central nervous system (CNS).

Objectives: In this study we described three rare primary extranodal presentations of DLBCL.

Methods: One case was nasopharyngeal DLBCL in a 13 years old boy who presented with recurrent nasal bleeding, obstruction, and discharge. Second case was breast DLBCL in a 72 years old female patient who had chief complaint of right breast lump for last 1 month without axillary lymphadenopathies. We had third case of DLBCL involving brain in a 50 years old male patient who had persistent headache and dizziness.

Case presentation: All the three cases had clinical suspicion of malignancy which was most common in that site.

Conclusion: Hence these cases emphasized the diagnostic importance of histopathology and immunohistochemistry in arriving at the correct diagnosis.