Mindfulness Based Therapy in Cancer Patients: Meta-Analysis

  1. Kamna Yadav ,
  2. Samanta Puspak Kumar Jena

Vol 6 No 3 (2021)

DOI 10.31557/apjcc.2021.6.3.329-338


Evidence suggested that mindfulness-based techniques have been effective in increasing psychological well-being. The present meta-analytic study aimed to examine the effects of mindfulness-based programmes on anxiety, and depression in cancer infected and survivors. Improvement in mindfulness across groups were also studied. Using various search items (e.g., MBCT, MBSR, Cancer). A systematic search of the electronic databases, reference list, and journal content lists were conducted from June 2011 to June 2020. Fourteen randomized controlled trials (N = 1831) evaluating effect of mindfulness in reducing anxiety and depression in cancer, measuring at pre-and-post interventions were included in this study. Random effects model was utilized for effect-size calculation. Interventions were between 5-8 weeks, with majority of participants been female (98.79%). Significant medium effect was observed for anxiety (g = 0.34) and depression (g = 0.32) with moderate heterogeneity and higher for mindfulness (g = 1.061) with high heterogeneity. Publication bias was not observed. Mindfulness has substantial effects in reducing anxiety and depression in cancer infected and survivors.


Steady escalation of interest has been observed in studying effects of mindfulness on psychological, and physiological factors. Mindfulness has its roots in Buddhism focussing on open and receptive mode [1]. From more than a decade, Mindfulness Based Cognitive Therapy [2] and Mindfulness Based Stress Reduction Therapy [3] has become widely used psychological tool in oncology. Both have been developed for group settings but recently a web-based studies have been done, focussing on individual intervention [4, 5] and shown to be effective on psychological distress [6], fatigue [7], fear of recurrence [8], anxiety [9], depression [10, 11]. It helps in disengaging individuals from repetitive negative thought patterns to doing mode helping them to use mindful processing of experience [12]. It helps to be focused and aware about the present moment rather than ruminating about the past (regretting about life, ruminating about causes of cancer) and future worries (fear of death, fear of recurrence) to reduce sufferings [12].

Individuals suffering from life-threatening illnesses are at increased risk for developing psychological and emotional distress, further effecting overall health [13]. Stronger evidence for increased level of mental health problems has been reported in individuals suffering from cancer, HIV/AIDS, and asthma [14, 15]. Approximately 38% of individuals with cancer reported of suffering from depression [16] and 18% from anxiety [17] and 35% of individuals reported of both anxiety and depression [18, 19]. Further interfering to cope with illness leading to high level of distress adversely affecting progression and survival of cancer [20, 21].

Earlier meta-analytic study [22] reported moderate effect size for anxiety and mood symptoms (Hedge’s g = 0.63, and 0.45) respectively. Decrease in depression (SMD: -0.37) and anxiety (SMD: -0.51), demonstrated evidence for the effectiveness of mindfulness but comprised a smaller number of RCTs leading to limited interpretability and generalizability of results [23]. In still another meta-analysis [24], showed moderate effect size of mindfulness on anxiety (Hedge’s g = 0.37) and depression (Hedge’s g = 0.44) but, included both Non-RCTs and RCTs thus, its interpretability is not limited to only RCTs.

It further lacks use of stringent design (Randomization with active controls as comparison). Since, several RCTs has been conducted and literature for mindfulness in cancer has doubled, systematic reviews have been done but this is the first meta-analysis, which is conducted by using stringent design that includes RCTs with active controls as comparison to see the effect of mindfulness on anxiety and depression in cancer patients.


Eligibility Criteria: Studies

RCTs were included from June’2011- June’2020 providing MBCT or MBSR interventions as per Kabat-Zinn [3] and Segal, Williams, and Teasdale [25] guidelines. Both, offline and online studies with at least 5-8 weeks program were considered. Published studies which were translated and available in English were eligible. Thus, unpublished studies, non-randomized, dissertations, study-protocols, and abstracts were excluded. This has reduced potentially lower methodological quality and selective reporting bias.

Types of Participants

Participants of any age and across 0-IV stage with current diagnosis of cancer, receiving no psychological disorder treatment were considered. Those who reported of suffering from any clinical psychological disorder were excluded. Participants were either invited to participate or were self-referred at intervention set-up.

Types of Interventions

Studies were eligible if they had a pre-post design with an outcome standard measure of anxiety and depression, with reported data sufficient for estimating effect size, wherein data was available for both the groups. Studies were excluded if deviations from the standard program such as mindfulness art therapy, music therapy, shortened week structure, no home-work assignments were observed. Studies combining MBCT/MBSR with other type of interventions (e.g., yoga) without calculating MBCT/MBSR results separately were excluded.

Types of Outcome Measures

Outcome measures were anxiety and depression, measured on a standard instrument, administered at pre-post to both the groups. Mindfulness was measured on various instruments including, revised version of Cognitive and Affective Mindfulness Scale (CAMS-R) [26], Kentucky Inventory of Mindfulness Skills (KIMS) [27] and Five Facets of Mindfulness Questionnaire (FFMQ) [28]. Although these questionnaires were similar in measuring mindfulness, appear to be dissimilar in terms of number and construct of mindfulness [29]. As FFMQ measured five factors (acting with awareness, describing with words, noticing sensations, nonreactivity to inner experience, nonjudging of experience), CAMS-R measured four factors (attention, awareness, acceptance, and present focus) whereas KIMS measured four factors (observing, describing, acting with awareness, and accepting without judgment). Outcome measures were excluded if unobtainable, not well-defined and lack of sufficient data.

Search Strategies

Search was conducted using five electronic data bases namely, PubMed, Cochrane, SAGE Pub, EMBASE and Google Scholar. The data were searched for English language publication using the following terms ‘mindfulness’, ‘cancer’, ‘mindfulness-based stress reduction’, ‘randomized controlled trial’, ‘mindfulness based cognitive therapy’, terms from year June’ 2011 to June’2020. Reference list of articles and reviews were also searched, and relevant studies were identified. Authors of the paper were also contacted through email and requested to share their research papers. Out of eight only three authors reverted with an access to their articles. Unpublished articles were excluded.

Selection Process

Selection was narrowed and studies were selected by title and list was made for all the studies done on cancer patients using Mindfulness intervention. Abstracts were reviewed from the list and relevant studies were retrieved in full form text and studies meeting eligibility criteria were selected for evaluation by meta-analysis.

Data Extraction

The studies were evaluated for the quality and content. The data was extracted using data extraction template based on minimum standards guidelines [30]. The data extraction sheet was developed to extract the data from the studies keeping the following points in mind: (1) Socio-demographic details of the participants including age, gender, type of cancer and stage of cancer, treatment, (2) intervention characteristics including type of mindfulness intervention (MBSR/MBCT), types of groups, number of sessions and participants in each group, results and limitations, (3) characteristics of outcome measures i.e., severity of depression, anxiety, and mindfulness.

Quality Assessment

Jadad scale [31] was used to assess methodological quality of studies (Table 1).

Table 1. Characteristics of Included Studies for Meta-analysis.

Study Diagnosis and Stage Percentage of Female Mean Age Groups N Sessions Anxiety g Depression g Mindfulness g Jadad Score
Hoffman et al (2012) [44] Breast Cancer Stage: 0-III 100 49 MBSR (103) CG (111) 214 8 weeks POMS 0.275 POMS 0.125 N/A N/A 4
Branstrom et al (2012) [53] Mixed: Stage: 0-III 76 51.8 MBSR (32) WL (39) 71 8 weeks HADS 0.195 HADS 0.134 FFMQ 0.305 3
Lengacher et al (2014) [54] Breast Cancer Stage: 0-III 100 55.3 MBSR (40) UC (42) 82 6 weeks STAI 0.398 CES-D 0.382 N/A N/A 4
Johns et al (2015) [57] Mixed, Stage: 0-III 94 57.25 MBSR (18), WL (17) 35 7 weeks GAD-7 0.034 PHQ-8 0.471 N/A N/A 4
Kingston et al (2015) [50] Mixed Stage: 0-III 62.5 23.4 MBCT (8) TAU (8) 16 8 weeks HADS 0.346 HADS 0.224 KIMS 0.618 3
Lengacher et al (2016) [51] Breast Cancer Stage: 0-III 100 56.6 MBSR (152) UC (147) 299 6 weeks STAI 0.109 CES-D 0.109 N/A N/A 3
Johns et al (2016) [55] Mixed Stage: 0-III 100 56.7 MBSR (35) UC (36) 71 8 weeks GAD 0.143 PHQ 0.051 N/A N/A 4
Sarenmalm et al (2017) [48] Breast Cancer Stage: 0-III 100 57.2 MBSR (67) UC (61) 128 8 weeks HADS 0.222 HADS 0.257 FFMQ 3.92 3
Reich et al (2017) [52] Breast Cancer Stage: 0-III 100 56 MBSR (155) UC (148) 303 6 weeks STAI 0.224 CES-D 0.174 CAMS-R 0.016 3
Johannsen et al (2017) [56] Breast Cancer Stage: 0-III 100 56.8 MBCT (67) WL (62) 129 8 weeks HADS 0.143 HADS 0.109 N/A N/A 2
Zhang et al (2017) [45] Leukaemia Stage: 0-III 56.92 47.6 MBSR (33) UC (32) 65 7 weeks SAS 1.484 SDS 1.167 N/A N/A 2
Compen et al (2018) [49] Mixed Stage: 0-III 69.5 51.7 MBCT (77) TAU (78) 155 8 weeks HADS 0.545 HADS 0.55 FFMQ 0.528 3
Liu et al (2019) [46] Differentiated Thyroid Cancer; Stage: 0-IV 70.58 43.2 MBSR (49) UC (53) 102 8 weeks SAS 0.816 SDS 0.879 N/A N/A 3
Nissen et al (2019) [47] Mixed; Stage: 0-III 91.33 59.7 MBCT (104) UC (46) 150 8 weeks STAI 0.233 BDI 0.236 N/A N/A 4

Note, Therapy; UC, Usual Care; WL, Wait List; AC, Active Controls; BAI, Beck Anxiety Inventory; BDI-I, Beck Depression Inventory-I; HADS, Hospital Anxiety & Depression Scale; POMS, Profile of Mood States; SCL 90-R, Symptom Check List 90-Revised; STAI, State Trait Anxiety Inventory; CES-D, Center for Epidemiologic Studies-Depression Scale; GAD-7, Patient Health Questionnaire Generalized Anxiety Disorder; PHQ-8, Patient Health Questionnaire 8-item Depression Scale; KIMS, Kentucky Inventory of Mindfulness Skills; SAS, Self-report Anxiety Scale; SDS, Self-report

Summary Measures

Mean anxiety and depression differences between intervention and control group from baseline to post intervention were outcome measures. Based on study, mean at baseline and post-intervention for both the groups were utilized with confidence interval, p-value and standard -deviation for effect-size calculation.

Statistical Analysis

Analysis was done using Comprehensive Meta- Analysis Software Version-3 [32]. Effect size (ESs) was calculated using hedge’s g for continuous measure of mindfulness, depression, and anxiety, using random-effect model. Hedge’s g is Cohen’s d variation [33] and can be expressed as small (0.2), medium (0.5) and large (0.8) [34]. Random effect model was utilized for heterogeneity (using Q and I2) and forest plots.

Risk of bias

Publication bias was assessed using funnel plots of study ESs and fail-safe N test. Asymmetry of the funnel test indicates publication bias. Inverted funnel with ESs symmetrical distribution indicates absence of bias [35].

Evidence Synthesis: Study Selection

Preferred Reporting Items for Systematic Review and Meta-Analyses was utilized for flow diagram [36], fourteen RCTs fulfilling the inclusion criteria were selected for meta-analysis. Refer Figure 1 for illustration of selection procedure.

Figure 1. Study Selection Process via PRISMA Guidelines (2009).

Comprehensive literature search produced 879 citations after adjusting duplicates; title screening led to removal of 673 protocols with obvious reason of not meeting inclusion criteria. 206 abstracts were screened and 168 were removed: reason being no mindfulness-based interventions, no randomized controlled trials. Due to full-text unavailability, three studies were excluded. Full-text examination of 38 studies revealed that 25 studies did not meet criteria, for example, few of the studies measured depression but did not measured anxiety [37-39], some measured anxiety but did not measured depression [40-42], few studies did not mention the mean of both the groups at baseline and post-intervention [40, 43]. Reference list scanning led to identification of one study [44]. No duplicate of the fourteen eligible studies were identified.

Study Characteristics: Participants

Of fourteen, six studies were conducted in U.S., six in Europe and two in China [45, 46]. Characteristics of studies are summarized in Table 2 and Table 3.

Table 2. Mean Comparison Across Variables in Included Studies (pre and post).

Study (Year) Anxiety scores Depression scores
Tools Pre-test Post-test Tools Pre-test Post-test
Hoffman et al. (2012) [44] POMS I=13.16 (7.2) I=10.32 (7.0) POMS I=12.79 (10) I=10 (9.95)
C=13.42 (7.24) C=13.36 (7.20) C=15.7 (12.79) C=14.96 (13.32)
Branstrom et al. (2012) [53] HADS I= 10.53 (4.7) I = 8.32 (4.40) HADS I= 6.41 (4.46) I= 4.85 (4.20)
C= 10.44 (4.59) C = 9.54 (5.10) C =7.18 (6.57) C= 6.57 (4.04)
Lengacher et al. (2014) [54] STAI I= 35.3 (12.0) I= 7.8 (9.80) CES-D I= 13.2 (12.0) I= 7.2 (4.60)
C= 40.4 (11.9) C= 6.4 (12.10) C= 14.2 (8.5) C= 4.0 (1.70)
Johns et al. (2015) [57] GAD-2 I= 5.83 (4.57) I= 3.91 (4.24) PHQ I= 7.89 (5.41) I= 4.58 (4.3)
C= 8.06 (4.90) C= 5.92 (4.18) C= 8.94 (5.17) C= 10.03 (9.8)
Kingston et al. (2015) [50] HADS I= 8.4 (5.50) I= 6.3 (7.50) HADS I= 8.0 (6.2) I= 3.3 (4.6)
C= 6.6 (4.80) C = 7.5 (5.10) C= 8.5 (6.4) C= 6.0 (6.8)
Lengacher et al. (2016) [51] STAI I= 16.5 (6.70) I= 15.7 (5.10) CES-D I= 16.5 (6.7) I= 15.7 (5.10)
C= 18.1 (7.50) C= 18.3 (6.40) C= 18.1 (7.5) C= 18.3 (6.40)
Johns et al. (2016) [55] GAD-2 I= 7.47 (5.50) I= 3.21 (3.76) PHQ-8 I= 11.35 (5.57) I= 6.27 (3.90)
C= 8.57 (5.31) C= 5.28 (4.27) C= 12.53 (4.90) C= 7.80 (4.67)
Sarenmalm et al. (2017) [48] HADS I= 6.5 (4.30) I= 6.0 (3.90) HADS I= 4.30 (3.70) I= 3.30 (3.30)
C= 4.8 (3.60) C= 5.1 (3.90) C= 3.50 (3.50) C= 3.80 (3.80)
Reich et al. (2017) [52] STAI I= 38.62 (12.3) I= 30.62 (12.3) CES-D I= 10.87 (6.89) I= 8.12 (5.45)
C=35.86 (11.29) C= 31.76 (13.2) C= 10.04 (6.46) C= 8.82 (6.02)
Johannsen et al. (2017) [56] HADS I= 16.5 (6.7) I= 15.7 (5.1) HADS I= 16.5 (6.7) I= 15.7 (5.1)
C= 18.1 (7.5) C= 18.3 (6.4) C= 18.1 (7.5) C= 18.3 (6.4)
Zhang et al. (2017) [45] SAS I= 56.83 (7.79) I= 40.91 (10.03) SDS I= 63.35 (8.61) I= 46.87 (7.48)
C= 56.91 (8.11) C= 59.74 (9.35) C= 61.87 (8.95) C= 58.93 (7.43)
Compen et al. (2018) [49] POMS I= 18.81 (6.7) I= 13.25 (6.33) POMS I= 18.81 (6.7) I= 13.25 (6.33)
C= 17.04 (5.79) C= 16.37 (6.50) C= 17.04 (5.79) C= 16.37 (6.5)
Liu et al. (2019) [46] SAS I= 59.58 (9.62) I= 65.24 (11.08) SDS I= 53.60 (8.61) I= 60.52 (9.73)
C= 58.72 (8.65) C= 77.37 (14.5) C= 54.36 (9.81) C= 73.64 (11.22)
Nissen et al. (2019) [47] STAI I= 41.7 (10.2) I= 37.5 (8.9) BDI-II I= 15.1 (7.4) I= 10.7 (6.6)
C= 42.7 (9.8) C= 41.8 (11.9) C= 17.6 (7.5) C= 15.6 (9.2)

Note, I, Intervention Group; C, Control Group; POMS, Profile of Mood States; HADS, Hospital Anxiety Depression Scale; STAI, State Trait Anxiety Inventory; GAD-2, Generalized Anxiety Disorder-2; SAS, Self-report Anxiety Scale; SDS, Self-report Depression Scale; CES-D, Center for Epidemiology Studies-Depression Scale; BDI-II, Beck Depression Inventory-II; PHQ, Patient Health Questionnaire-8 item depression scale

Table 3. Mean Comparison of Mindfulness Across Groups (pre and post).

Study (Year) Mindfulness Scores
Tool Pre-test Post-test
Branstrom et al. (2012) [53] FFMQ I= 123.45 (32.74) I= 140.17 (29.02)
C= 117.65 (32.69) C= 120.53 (32.57)
Kingston et al. (2015) [50] KIMS I= 118.1 (17.4) I= 124.4 (13.6)
C= 123.9 (15.8) C= 117.0 (9.3)
Sarenmalm et al. (2017) [48] FFMQ I= 16.4 (3.7) I = 17.1 (3.0)
C= 17.1 (3.5) C= 17.1 (3.3)
Reich et al. (2017) [52] CAMS-R I= 34.04 (6.61) I= 35.20 (7.55)
C= 35.37 (7.17) C= 36.71 (7.52)
Compen et al. (2018) [49] FFMQ I= 72.43 (9.69) I= 82.02 (10.42)
C= 75.75 (11.18) C= 77.26 (11.80)

Note, I, Intervention Group; C, Control Group; CAMS-R, Cognitive and Affective Mindfulness Scale-Revised; FFMQ, Five-facet of Mindfulness Scale; KIMS, Kentucky Inventory of Mindfulness Skills


All RCTs were retrieved from June’ 2011 to June’ 2020 published in English. All participants received either MBSR (K = 9) or MBCT (K = 3) intervention offline except one study [47] for depression and anxiety symptoms. Twelve studies were two-armed randomized controlled trial, and two studies were three-armed controlled trial [48, 49]. Data was taken for two groups i.e., Mindfulness group and control group from 3-armed controlled group trial studies. Out of all 14 studies, eight studies compared MBSR to Usual Care (UC), six compared MBSR to Wait-List controls offering delayed intervention. One study provided supportive counselling [50] and one study offered convention care including medication, normal living conditions such as oral care, safety, diet, self-protection [46].


Sample size of fourteen studies varied from 16 [50] to 299 [51, 52], yielding 1831 participants, of these1806 were female participants. Of these 903 were in mindfulness intervention group and 928 in control group (Table 2). Six studies had only breast cancer diagnosed participants and remaining eight studies had mixed cancer site with stage 0-III (K=13) and one study had participants with 0-IV stage [46]. The mean age of the participants was 51.26 years (range:16-80) and majority of participants were women diagnosed with breast cancer (84.7%). All studies reported on time data with mean, median, standard deviation, or interval. Since diagnosis, the average mean time across studies was 18.5 months (range: 2weeks–24months). No difference was observed between treatment and control group on diagnosis and time. Among 14 randomized controlled studies, eight studies reported active chemotherapy, radiation (range: 35.7%-70.64%), one study reported oral chemotherapy [50], active radioiodine therapy [45] and three studies had no active treatment [47, 53, 54]. At baseline no significant difference in terms of age, education, marital status, employment, cancer stage, cancer type, income, time since diagnosis between treatment and control group was observed.

Follow-up assessment was observed from baseline (minimum) to 6 months (maximum). Specifically, six-month follow up were seen in three studies [53, 55, 56], five studies showed three-month follow-up [44, 46, 48, 51, 52], one- month follow-up was observed in Johns et al., 2015 and remaining five studies showed no follow-up [45, 47, 49, 50, 54].


Interventions were based on Jon Kabat-Zinn (MBSR, 1992) and William, Teasdale & Seagal (MBCT, 2002) guidelines/protocol. Length of interventions varied from 5 weeks [45], 6 weeks [51, 52, 54] to 8 weeks [44, 46-50, 53, 55, 56], except two studies provided 7-week intervention [45, 57]. Mindfulness involved weekly 1.5 hours [50], 2 to 2.5 hours [49] session with 6-days a week home practice assignment guided by audio files. One day 6-hour retreat at 6 weeks was observed [44]. Sessions included guided instructions, handouts, readings, guided audios, home assignments. Formal mindfulness practices include body-scan, yoga-based mindfulness, sitting meditation, breathing space, and didactic teachings. MBCT included formal mindfulness practices with cognitive based techniques such as psychoeducation, exercises targeting depression and anxiety including rumination and physical problem related to cancer [50]. Intervention was delivered by trained professional i.e., psychologist in MBCT with prior experience of 3 years to 9 years across studies. Intervention was provided offline i.e., face to face across studies, except one study wherein intervention was provided online [47].


Depression and anxiety measures used in studies to obtain ES can be seen from Table 2. Out of all studies, five studies measured mindfulness using either Cognitive & Affective Mindfulness Scale-Revised [26] (K = 1) [52], Kentucky Inventory of Mindfulness Skills [27] (K=1) [50] and Five-Facet Mindfulness Questionnaire [27] (K = 3) [48, 59, 53]. Effect size was calculated using difference in means and was not influenced by difference in mindfulness scales.

Assessment of risk of bias

Methodological quality varied across studies (Table 4).

Table 4. Assessment of Risk of Bias.

Study (Year) Blinding Allocation Concealment Comparison of Groups on outcome measure at baseline Dropouts & withdrawal details Intent to treat analysis
Hoffman et al. (2012) [44] Yes Yes Yes Yes Yes
Branstrom et al. (2012) [53] No Yes Yes No Yes
Lengacher et al. (2014) [54] Yes Yes Yes Yes Yes
Johns et al. (2015) [57] Yes Yes Yes Yes Yes
Kingston et al. (2015) [50] No Yes Yes Yes Yes
Lengacher et al. (2016) [51] No Yes Yes Yes Yes
Johns et al. (2016) [55] Yes Yes Yes Yes Yes
Sarenmalm et al. (2017) [48] No Yes Yes No Yes
Reich et al. (2017) [52] No No Yes No Yes
Johannsen et al. (2017) [56] No No Yes Yes Yes
Zhang et al. (2017) [45] No No Yes No Yes
Compen et al. (2018) [49] No Yes Yes Yes Yes
Liu et al. (2019) [46] No Yes Yes No Yes
Nissen et al. (2019) [47] Yes Yes Yes Yes Yes

Note, Adapted from Higgins and Altman (2008).


Essential data was available for all the fourteen RCTs eligible for estimating effect size for anxiety and depression pre-post intervention (Table 2). Only five studies measured mindfulness. Means and standard deviations at pre and post-test was provided for both groups across all the studies. Refer to Table 2. Estimated effect size (Hedge’s g) and statistical significance, confidence interval, Z-value, and assigned random weight for outcome measures can be observed through Figure 2 and Figure 3, respectively.

Figure 2. Forest Plot Demonstrating Intervention Effect on Anxiety: Pre-post between Group Effect.

Figure 3. Forest Plot Demonstrating Intervention Effect on Depression: Pre-post between Group Effect.

Synthesis of result

Effects on anxiety

Analysis of all fourteen studies using random effects in comparison to control group shows decreased anxiety (g = 0.346; CI = 95%; p = 0.000), indicating medium effect. Heterogeneity was moderate (Q = 31.199; p = 0.003; I2 = 58.332) and outliner was not detected. Removal of pilot study (N = 35) (Johns et al., 2015) increased the effect (g = 0.360; CI = 95%; p = 0.000) and higher heterogeneity level was observed (Q = 30.470; p = 0.002; I2 = 60.617), without outliners.

Effects on depression

In analysis of all fourteen RCTs, mindfulness group in comparison to control group, demonstrated medium effect size (g = 0.327; CI = 95%; p = 0.000), indicating reduced depression. Level of heterogeneity was moderate (Q = 28.224; p = 0.008; I2 = 53.940), with no outliner. Removal of a study with small sample size (N = 08) (Kingston et al., 2015) showed slightly increased effect size (g = 0.330; CI = 95%; p = 0.000) and increased heterogeneity (Q = 28.217; p = 0.005; I2 = 57.472), without outliners.

Effects on mindfulness

In pooled data of five studies, treatment group in comparison to control group demonstrated a high effect in improving mindfulness (g = 1.061; CI = 95%; p = 0.049) (Figure 4).

Figure 4. Forest Plot for Mindfulness: Pre-post.

With no outliner detected, level of heterogeneity was high (Q = 133.684; p = 0.000; I2 = 97.008).

Deletion of study Reich et al. (2016) showed higher effect size (g = 1.341; CI = 95%; p = 0.082) with reduced heterogeneity level (Q = 100.816; p = 0.000; I2 = 97.024).

Risk of bias across studies

Analysis demonstrated moderate to higher level of heterogeneity for intervention effects on outcome measures. High heterogeneity for mindfulness effects on intervention group was observed. To observe relation of heterogeneity to publication bias, demonstrating intervention effect on anxiety, and depression, funnel plot was developed. Johns et al. (2015) study was observed to made asymmetrical plot. Absence of publication bias was observed due to lower effect of afore mentioned study. Trim-and-fill method [35] demonstrated no point change of random effect model, showing no missing studies had changes in the effect size of the plot. Similar effects were observed in mindfulness effect distribution in comparison to anxiety and depression.

Publication Bias

Fail-safe n for depression and anxiety appeared to exceed the criteria for robustness of results. No evidence of asymmetry is observed for depression t (6.22), p < 0.000 and anxiety t (6.78), p < 0.000 symptoms using Egger’s regression test.


Analysis outlines the effect of mindfulness on reduction of anxiety and depression and increment in mindfulness in cancer-infected and survivors with control group after intervention. Literature search led to fourteen RCTs conducted for reducing anxiety, depression and improved psychological well-being. Participants of all included studies were predominately females with diagnosis of breast cancer.

Mindfulness has become popular intervention amongst cancer individuals, but very little is known about its efficacy. Previously done meta-analysis [22] does not emphasised on mindfulness to decrease anxiety and depression in cancer infected and survivors but included differential population or effects on mental health and psychological problems [58]. Number of studies has been doubled in a brief amount of time, further, allowing for a more comprehensive meta-analysis to explore the effects of MBCT/MBSR for cancer patients particularly for RCTs.

Pooled analysis results suggested ES ranging from low to moderate range for reduction of depression (Hedge’s g = 0.32) and anxiety (Hedge’s g = 0.36) indicating robust and significant effect. Heterogeneity for studies was found out to be moderate for depression (53.940, p < 0.008) and medium for anxiety (58.332, p < 0.003) within and between studies and high for mindfulness (97.008, p < 0.000). Quality result for all the studies were found out to be 3.2 suggesting reliable results. Piet, Wurtzen and Zachariae (2012) represents systematic review of mindfulness, allowing for comparison with findings from present study. There RCTs findings matched our findings for anxiety and depression symptoms. Hoffman et al (2010) in their meta-analysis included wide range of medical and psychological disorders, they also included number of subgroup analyses showing pre-post effect size for anxiety (g = 0.63) and (0.45) and depression (g = 0.45, respectively). These were based on few studies.

Mindfulness has been effective in decreasing depression and anxiety symptoms, by targeting rumination and emotional avoidance, maintaining processes across anxiety and depression [59]. It is cost-effective treatment, aimed at improving emotion regulation through increased attention and acceptance. Mindfulness therapy can be used along with other interventions, focusing on change through active problem solving.


First study investigating only RCTs to see the effect of Mindfulness (MBSR/MBCT) on anxiety and depression symptoms in cancer infected and survivors. Study aims, inclusion criteria, method of analysis were prespecified and highly focussed. Random-effects model was used [34].


This meta-analysis is limited by basic statistical assumptions and inclusion criteria. Majority of individuals were diagnosed with breast cancer but differ with cancer stage and time since diagnosis, both between and within studies. Effects of mindfulness for different individual makes it difficult to come at a conclusion. It cannot be generalized to male cancer individuals as majority of participants were female with breast cancer.

Implications for practice

Evidence suggests that mindfulness interventions are delivered effectively in cancer patients [45, 46, 53] and survivors [47, 55]. Previous meta-analysis included studies on cancer survivors [23], non-RCTs [22, 24], studied either effect on depression [60], this is the first meta-analysis including RCTs of adult cancer infected i.e., patients on active treatment such as chemotherapy [45, 48, 49, 52, 56], radio-active iodine therapy [46]. Finding indicates that mindfulness intervention for cancer patients and survivors substantially decrease anxiety and depression and improved mindfulness. Given access to cancer patients, especially during active-treatment, mindfulness can be effective compared to no psychological interventions.

Implications for research

Areas for future RCTs in cancer patients using mindfulness was identified: 1) comparison of face to face with internet-based mindfulness interventions with same content, involving a control group, 2) assessing home-based practices of mindfulness interventions as it is an integral part of the intervention, 3) assessing interventions effect on subgroups when possible and applicable e.g., by gender, income, age, occupation, and education, 4) since very few studies measured the increment of mindfulness at pre-post and even at follow-up, this can be future direction for research. Methodological quality characteristics including blinding, treatment adherence or non-adherence shall be reported by the researchers. Feedbacks from participants in research should be included. There are very few studies on effect of mindfulness on young adolescence (cancer) psychological well-being, considering it as need of an hour, warrants investigation.

Supplementary data to this article can be found online.

Declaration of Conflicting Interests

Author(s) declare that there is no financial, authorship, publication conflict of interest of this article.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for- profit sectors.


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© Asian Pacific Journal of Cancer Care , 2021

Author Details

Kamna Yadav

Samanta Puspak Kumar Jena
Affiliation not stated

How to Cite

Yadav, K., & Kumar Jena, S. P. (2021). Mindfulness Based Therapy in Cancer Patients: Meta-Analysis. Asian Pacific Journal of Cancer Care, 6(3), 329-338. https://doi.org/10.31557/apjcc.2021.6.3.329-338
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